摘要
目的 :观察原花青素 (procyanidin ,PC)对大鼠心肌缺血再灌注损伤的保护作用。方法 :结扎大鼠冠状动脉左前降支 (LAD) 40min ,复灌 12 0min后复制出大鼠心肌缺血再灌注损伤模型 ,观察PC对大鼠心肌酶学、心梗面积和脂质过氧化的影响。结果 :PC能减少心肌细胞磷酸肌酸激酶 (CPK)和乳酸脱氢酶 (LDH)的释放 ,明显缩小心肌梗死面积 ,能显著提高大鼠血清和心肌组织中超氧化物歧化酶 (SOD)活性 ,降低心肌和血清脂质过氧化代谢产物丙二醛(MDA)含量。结论 :PC对大鼠心肌缺血再灌注损伤有保护作用 ,其机制可能与清除自由基 。
AIM: To inverstigate the protective effects of procyanidin on myocardial ischemia reperfusion injury in rats. METHODS: Myocardial ischemia reperfusion injury models were established by the ligation of left desending coronary artery for 40 min and referfusion for 120 min in rats, and the influence of procyanidin on enzymes of myocardial, myocardial infarction size and lipid peroxide were observed. RESULTS: Procyanidin decreased myocardial creatine phosphokinase (CPK) and lactate dehydrogenase (LDH) release significantly diminished myocardial infarction size, raised the activity of superoxide dismutase (SOD), reduced malondialdehyde (MDA) content in myocardial and serum in comparison with the control. CONCLUSION: Procyanidin has a protective effect on myocardial ischemia reperfusion injury. The action is related to the inhibition of the free radical and subsequent lipid peroxidation.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2003年第2期173-175,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
