摘要
目的:探讨恶性血液病患者清髓异基因造血干细胞移植(allo-HSCT)后的生育情况。方法:1 008例接受allo-HSCT的恶性血液病患者中,9例(0.9%)男性患者的配偶发生了15次妊娠。其中6例患者接受亲属间单倍体移植。预处理方案均为清髓性改良白消安/环磷酰胺方案。结果:9例患者白细胞植活中位时间为14(11~26)d,血小板植活中位时间为14(8~19)d;5例发生急性移植物抗宿主病,7例发生慢性移植物抗宿主病。15次妊娠中,9次(60%)婴儿安全出生,且所有婴儿出生体重及生长发育状况均正常。结论:接受清髓预处理allo-HSCT,少数患者仍可保存其生育能力,建议拟接受allo-HSCT的育龄恶性血液病患者,均应在移植前后接受生育咨询。
Objective:To explore the fertility in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation(allo-HSCT).Method:Among the 1 008patients with hematologic malignancies who received allo-HSCT,9couples(0.9%)of the male patients had 15times of pregnancy.Result:The median times of leukocyte and platelet engraftment were 14(11to 26)days and 14(8to 19)days in 9patients,respectively.Six of the 9patients received allo-HSCT from the related haploidentical donors.The conditioning regimen used was myeloablative modified BU/CY.Five of these 9 patients developed acute graft-versus-host disease(GVHD)and 7cases had chronic GVHD.Nine times(60%)of the 15times of pregnancy were with normal delivery.The body weights and scores at birth were normal.Conclusion:A few of patients after haploidentical HSCT could preserve fertility.Consultation of fertility before and after allo-HSCT is recommended for all recipients in childbearing age.
出处
《临床血液学杂志》
CAS
2014年第A02期199-202,共4页
Journal of Clinical Hematology
关键词
妊娠
清髓异基因造血干细胞移植
恶性血液病
pregnancy
myeloablative allogeneic hematopoietic stem cell transplantation
hematologic malig-nancy
