摘要
随着肝硬化病情进展,患者身体成分组成发生显著变化,肌少症是肝硬化患者尤其是失代偿肝硬化常见的合并症之一。约30%～70%的肝硬化患者存在肌少症,严重影响患者生存期,其与肝性脑病的发生密切相关,并且可能增加患者的感染风险。肌少症、肌肉脂肪化可作为肝细胞癌的不良预后指标,增加肝癌复发风险。综述了肌少症的相关定义、与肝硬化的关系及其评估和临床管理相关研究进展。
As the disease progresses,there is a significant change in the body composition of patients with liver cirrhosis,and sarcopenia is one of the common complications in liver cirrhosis,especially in decompensated cirrhosis.About 30%-70%of patients with liver cirrhosis have sarcopenia,which greatly affects patients’survival and is closely associated with the development of hepatic encephalopathy.Sarcopenia may also increase the risk of infection.Sarcopenia and muscle fatty degeneration can be used as poor prognostic indicators of hepatocellular carcinoma and may increase the risk of recurrence of liver cancer.This article reviews the research advances in the definition of sarcopenia,the association of sarcopenia with liver cirrhosis,and assessment and clinical management of sarcopenia.
作者
韩芳
韩涛
梁静
HAN Fang;HAN Tao;LIANG Jing(Department of Hepatology,Tianjin Third Central Hospital,Tianjin 300170,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2019年第4期891-894,共4页
Journal of Clinical Hepatology
关键词
肝硬化
肌疾病
萎缩性
肌
骨骼
综述
liver cirrhosis
muscular disorders,atrophic
muscle,skeletal
review
