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过氧化体增殖物激活型受体对心肌能量代谢调控的病理生理机制 被引量：5

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摘要 过氧化体增殖物激活型受体是调节编码脂肪酸 β -氧化相关酶类基因的重要转录调节因子 ,在调节心肌能量代谢中发挥重要作用。心肌肥厚和心力衰竭时心肌细胞过氧化体增殖物激活型受体α的表达和转录调控活性均降低 ,脂肪酸 β-氧化的相关酶类基因 (过氧化体增殖物激活型受体α的靶基因 )的表达在转录水平降低 ,说明过氧化体增殖物激活型受体α可能通过信号转导途径影响心肌的能量代谢。过氧化体增殖物激活型受体γ激活剂可增加心肌细胞对葡萄糖的氧化和利用 ,减轻心肌缺血 再灌注损伤和心肌肥厚的程度 ,有潜在的心脏保护作用。
作者 叶平
机构地区 中国人民解放军总医院老年心内科
出处 《中国动脉硬化杂志》 CAS CSCD 2003年第1期81-83,共3页 Chinese Journal of Arteriosclerosis
关键词 过氧化体增殖物激活型受体 心肌能量代谢调控 病理生理学
分类号 R542.2 [医药卫生—心血管疾病]
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参考文献18

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同被引文献59

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中国动脉硬化杂志
2003年 第1期

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