摘要
目的 检测内皮素 1(ET 1)在裂孔性视网膜脱离 (RRD)不同病期玻璃体液中的水平。方法 2 0例RRD患者采取血液和玻璃体液 ,玻璃体液分为视网膜下液 (PVRA/B级 ) ,玻璃体液 (PVRC/D级 )各 10例 ;10例尸眼取玻璃体液 ,10例正常人取血液 ,10例玻璃体积血 (VH)患者取血液和玻璃体液 ;用放射免疫测定的方法检测其质量浓度。用单因素方差分析统计其意义。结果 玻璃体标本中除正常对照 10例、VH的 3例和PVR C/D级的 3例外均检测出ET 1质量浓度。血浆各组间除正常对照组与PVRC/D组、PVRA/B和PVR C/D组外均有显著性差异 (P <0 0 1)。玻璃体各组间除正常对照组与VH组、VH与PVRC/D组外均有显著性差异 (P <0 0 5 )。结论 ET 1在视网膜脱离早期玻璃体内质量浓度较高 ,而在眼内增殖的晚期则下降 。
ObjectiveTo investigate levels of endothelin 1 (ET 1) in vitreous in patients with rhegmatogenous retinal detachment (RRD).MethodsET 1 plasma and vitreous samples were determined by radioimmunoassay from 20 patients with RRD in the age of 20～40 and 10 patients with vitreous hemorrhage in the age of 40～50. Normal plasma samples were obtained from 10 healthy, whose age and gender matched control subjects and normal vitreous samples from 10 sudden death donor eyes. ResultsThe ET 1 was not detected from vitreous samples in all of the normal controls, 3 of 10 patients with PVR grade C and D and 3 of 10 with vitreous hemorrhage(VH). The level of ET 1 in plasma had significant intergroup differences ( P < 0 01) except for normal control and PVR grade C/D group, PVR grade A/B and PVR grade C/D group, respectively. The level of ET 1 in vitreous had significant intergroup differences ( P < 0 05) except for normal control and VH, VH and PVR grade C/D, respectively. ConclusionsThese findings may reflect the states of the vitreous proliferation through the development of the RRD.
出处
《眼科研究》
CSCD
北大核心
2003年第2期116-117,共2页
Chinese Ophthalmic Research
基金
国家自然科学基金资助项目 (39970 780 )
