摘要
目的 :观察胰岛素抵抗与脑卒中的关系。方法 :脑卒中组 6 7例 ,其中脑梗死 (CI)者 2 4例 ,腔隙性脑梗死 (LI)者 18例 ,脑出血 (ICH)者 2 5例。检测各组患者的空腹血糖和餐前、餐后 2小时的C肽及胰岛素浓度 ,并计算其胰岛素敏感指数 ,同时设对照组 14例进行对比观察。结果 :CI组及LI组的胰岛素敏感指数显著低于对照组 ,ICH组与对照组对比无显著性差异。脑卒中组中的胰岛素抵抗者有 2 6例 ,占 38 8% ,主要见于肥胖或甘油三脂、低密度脂蛋白胆固醇、尿酸、载脂蛋白B、高密度脂蛋白等指标中有三项以上异常的患者。结论 :胰岛素抵抗与缺血性脑卒中有密切关系 ,早期通过控制饮食、增加运动、药物治疗等方法降低人群的胰岛素抵抗 。
Objective:To study the relationship between insulin resistance(IR)and cerebral stroke.Methods:Sixty-seven patients with cerebral stroke were divided into cerebral infarction(CI)group(24 cases)\,lacunar infarction(LI)group(18 cases)and intracerebral hemorrhage(ICH)group(25 cases).Their fasting blood-glucose\,the concentration of C-peptide and insulin before and after breakfast two hours were measured,and the insulin sensitive indexes(ISI)were calculated and compared with those of the normal control group(14 cases).Results:The ISI of CI group and LI group were significantly lower than those of the normal control group( P <0.05).No significant differences were found between the ICH group and the normal control group( P>0.05).The cerebral stroke patients with IR(26 cases)were usually obese or had abnormalities of more than three lipid biochemistry indices(38\^8%).Conclusions:There was strong relationship between IR and ischemic cerebral stroke,Early intervention to decrease IR through diet\,sports and medicines in community population would be beneficial to the prevention of cerebral stroke.
出处
《中国冶金工业医学杂志》
2003年第2期77-79,共3页
Chinese Medical Journal of Metallurgical industry
