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生长抑素在胃癌发病机制中作用的探讨 被引量:2

Effect of somatostatin in pathogenesis of gastric carcinoma
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摘要 为研究胃癌组织中生长抑素 (SS)与c Fos ,c Jun表达的相互关系 ,探讨其在胃癌发生发展过程中的作用。应用免疫组化S P法 ,检测 57例胃癌组织中生长抑素和c Fos ,c Jun的分布及其定位 ,结合胃癌组织分级、淋巴结转移分析其表达特征及意义。结果显示 :胃癌组织中SS阳性表达率为 36 .2 % ;c Fos及c Jun阳性表达率分别为 75 .4%和 70 .2 % ;c Fos和c Jun的表达在SS阳性及SS阴性胃癌组中有显著性差异 (P <0 .0 1 ) ;c Fos,c Jun与SS表达有拮抗性 ,随着胃癌分期的增加 ,SS ,c Fos和c Jun的表达亦呈下降趋势 ;SS表达与胃癌的淋巴结转移有显著相关性 ;c Fos和c Jun表达与胃癌的淋巴结转移无关。生长抑素通过抑制c Fos和c Jun参与了胃癌细胞增殖分化过程。生长抑素对 c Fos和c Jun
出处 《中国普通外科杂志》 CAS CSCD 2003年第1期51-53,共3页 China Journal of General Surgery
基金 中科院西部之光计划项目 ( 2 0 0 0 - 0 132 )
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参考文献12

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二级参考文献7

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