摘要
目的 研究激素敏感型肾病综合征 (SSNS)患儿骨生化标志水平的变化特点及意义。方法 应用放射免疫分析法检测 2 4例SSNS患儿活动期和缓解期血清骨钙素 (OC)、Ⅰ型前胶原氨基端伸展肽 (PINP)、Ⅰ型胶原羧基端关联肽原 (ICTP)水平 ,与 19例年龄、性别相匹配正常对照儿童进行比较。结果 SSNS患儿活动期血OC[(11 37± 3 5 4 ) μg/L]、PINP[(339 6 4± 12 6 6 ) μg/L]和缓解期血OC[(6 6 1± 1 74 ) μg/L]、PINP[(175 71±11 97) μg/L]均低于对照组血OC[(18 4 4± 4 35 ) μg/L]、PINP[(471 30± 10 6 2 ) μg/L],分别为 P <0 0 5和P <0 0 1。活动期血ICTP[(19 0 5± 4 5 6 ) μg/L]与对照组 [(19 5 6± 3 6 2 ) μg/L]相比 ,差别无统计学意义 ,P >0 0 5 ;而缓解期血ICTP水平升高 ,P <0 0 1。活动期和缓解期血OC水平和PINP水平均呈正相关 (分别r =0 85 ,P <0 0 1和r =0 71,P <0 0 1)。结论 SSNS患儿活动期骨形成生化标志水平降低 ,骨吸收生化标志水平无变化 ;缓解期骨形成生化标志水平进一步下降 ,骨吸收生化标志水平升高。
Objective To study the variation of serum biochemical bone markers in patients with steroid sensitive nephrotic syndrome(SSNS).Methods Serum levels of osteocalcin(OC), aminoterminal propeptide of type I procollagen(PINP) and carboxyterminal telopeptide of type I collagen(ICTP) were assayed by radioimmunoassay in 24 patients with SSNS at the active and remission stages and in 19 normal age and sex matched controls.Results Serum levels of OC\[(11 37±3 54)μg/L,(6 61±1 74)μg/L,respectively\] and PINP\[(339 64±12 66)μg/L, (175 71±11 97)μg/L, respectively\] in patients at the active stage and remission stage were significantly lower than those in control group\[OC(18 44±4 35)μg/L, PINP(471 3±10 62)μg/L\] (P<0 05 and P<0 01,respectively) There was no difference in the serum levels of ICTP between the patients at the active stage and the healthy controls(P>0 05).Serum levels of OC and PINP in patients at the remission stage were further significantly lower than those at active stage(P<0 01). Serum levels of ICTP in patients at the remission stage were significantly higher than those at active stage(P<0 01).The serum level of PINP correlated positively with the serum level of OC.Conclusion Serum levels of biochemical bone formation markers is decreased in patients with SSNS at the active stage, but serum levels of biochemical bone resorption markers has no change. In remission stage, serum levels of biochemical bone formation markers is furthur decreased, but serum levels of biochemical bone resorption markers is increased.
出处
《中国实用儿科杂志》
CSCD
北大核心
2003年第2期89-91,共3页
Chinese Journal of Practical Pediatrics
