摘要
目的评价通心络加用氟桂利嗪(西比灵)(B组)治疗椎基底动脉供血不足102例的疗效,并与单用西比灵(A组)治疗77例作对照观察。方法A组给西比灵10mg口服,1次/d;B组在A组基础上加用通心络3-4粒,3次/d。一疗程15d,间歇5-7d,部分有效病人视病情可行第2疗程治疗。结果 一疗程后评定,A、B两组各痊愈40例和73例,显效15例和20例,有效11例和5例,无效11例和4例。A、B两组的痊愈率为52％和71％(r2=7.94,P<0.01),显效率分别为71.4％(55/77)和91.2％(93/102)(r2=12.96,P<0.01),总有效率85.7％(66/77)和96.1％(98/102),(r2=4.69,P<0.05),有效病人随访2月未复发率为63.6％(42/66)和76.5％(75/98)(r2=6.31,P<0.05)。结论通心络合用西比灵治疗椎基底动脉供血不足较单用西比灵治疗效果更加显著。因两药均易通过血脑屏障,针对脑血管的流体力学特点、血液成分及动力学状态对椎基底动脉供血不足发生、发展和转归的各种因素和环节有协同作用,以增加缺血区脑血流量和氧供,恢复脑细胞功能,促进其缺血症状的改善。
Objective To eveluate the effect of the treament of vertebralis basilaris ischemia with Tongxin Luo adding flunarizine(group B), 77cases were only treated with flunarizine(group A)were compared with group B.Methods Patients in group A were treated with flunarizine 10 mg (Po) , one time everyday. For the patients in group B, they were treated with eating TongxinLuo as3-4#(Po) three times every day on the base of group A. 15-day was designed as one treatment time .Then proceeded the next treatment time according to patient's condition after 5 - 7 days of the end of the first one. Results Estimating after the first treatment time in group A and group B respectively: 40 cases and 70 cases were cured. Remarkable effective cases were 15 and 20. Effective cases were 11 and 5. Noeffective cases were 11 and 4;care ratio is 52% and 71% in group A and group B respectively. (x2 = 7.94, P < 0.01) .Remarkable effective ratio is 71.4% in group A and 91.2% in group B(x2 = 12.96, P < 0.01) .Total effective ratio is 85.7% (group A) and 96.1 %(group B) .The effective cases were followed for two months. The ratio of recur is 63.6% in group A and 76.5% in group B(x2 = 6.31, P < 0.05) .Conclusion Tongxin Luo adding flunarizine is better than only flunarizine, and the treatment of vertebralis artery and basilaris artery ischemia.The two drugs also can transit through blood-brain barrier. As to the character of cerebrovascular hemodynamics, bloodstream component and fluid dynamic station. The drugs can play its synergetic effect to increase cerebral blood flow and oxygen provision according to the elements and procedures of generation, development and result of vertebrial artery and basilar artery ischemia. At last, to recover the function of brain cell and to promote the ischemia symptom.
出处
《河南实用神经疾病杂志》
2003年第2期4-6,共3页
Henan Journal of Practical Nervous Diseases
