摘要
目的 探讨IVF -ET治疗周期中血清性激素水平与妊娠率的关系。方法 对 134个采用促性腺激素释放激素激动剂 促卵泡生成素 绒毛膜促性腺激素 (GnRH -a FSH hCG)方案促排卵的IVF和单精子胞浆内注射 (ICSI)周期 ,采用时间分辨荧光读数法 ,在注射hCG日测定促卵泡生成激素 (FSH)、黄体生成素 (LH)、雌二醇 (E2 )、孕酮 (P)、泌乳素(PRL) ,在胚胎移植 (ET)日测定E2、P。结果 注射hCG日FSH、LH、E2、P、PRL均与妊娠无关 ;但P E2与妊娠有关。当P E2 <0 5ng ml时 ,妊娠率最高 (P =0 0 2 4)。ET日 ,雌激素水平与妊娠无关 ,孕激素水平与妊娠率有显著性差异 ,P≥ 6 0ng ml时临床妊娠率达 44 4% (P =0 0 0 3)。结论 在IVF和ICSI周期中 ,注射hCG日的P E与ET日的P值均与妊娠结局有关。该两项是预测IVF -ET临床妊娠率的一个较好的指标。若P值偏低 ,可在黄体期加强黄体支持以提高妊娠率。
Objective To approach the relationship between the serum sexual hormone and pregnant rate in vitro fertilization and embryo transfer.Methods 134 IVF and ICSI cycles were underwent in the long protocol for control superovulation with GnRH-a/FSH/hCG.The follicle-stimulation hormone(FSH),estradiol(E 2),luteal hormone(LH),progesterone(P)and prolactin(PRL)were measured on the day of hCG administration.The E 2 and P levels were measured on the day of embryo transfer(ET).Results FSH,LH,E 2,P and PRL were not related to pregnant rate on the day of hCG administration;but P/E 2 was related to it.The pregnant rate was higher when P/E 2 less than 0.5ng/ml(P=0.024).E 2 level did not influence the pregnancy. However,P level was significantly related to the clinical pregnant rate when P≥60ng/ml(P=0.003).Conclusion Both P/E 2 on the day of hCG and P level on the day of embryo transfer were related with pregnant outcome in IVF and ICSI cycles .They are better predictive parameter of successful pregnancy.If P level is lower, it will contribute to improve pregnant rate to support progesterone.
出处
《云南医药》
CAS
2003年第1期3-4,共2页
Medicine and Pharmacy of Yunnan
