摘要
目的 了解有冠心病 (CHD)家族史儿童脂质三角 [低密度脂蛋白 胆固醇 (LDL C) ,高密度脂蛋白 胆固醇 (HDL C)和甘油三脂 (TG) ]有无异常。方法 对 83例有冠心病家族史的儿童检测血浆TG ,LDL C和HDL C浓度 ,计算LDL C/HDL C ,以无CHD家族史的健康儿童作为对照。结果 与对照组比较 ,有CHD家族史的儿童血TG ,LDL C浓度明显增高 [(1.4 6± 0 .6 3)mmol/Lvs (0 .84± 0 .4 3)mmol/L ,(2 .0 9± 1.13)mmol/Lvs(0 .96± 0 .87)mmol/L],HDL C水平降低 [(1.4 8± 0 .4 8)mmol/Lvs (1.72± 0 .5 3)mmol/L],LDL C/HDL C升高(1.71± 1.2 9vs 0 .96± 0 .6 8) (P <0 .0 1) ;TG >1.7mmol/L及LDL C/HDL C >2 .5的发生率明显增高 (2 0 .5 %vs1.2 % ) (P 均 <0 .0 1)。有CHD家族史的男童与女童比较 ,脂质三角差异无显著性 (P >0 .0 5 )。有早发CHD家族史的儿童血TG ,LDL C水平 [(1.86± 0 .6 3) ,(3.12± 1.32 )mmol/L]高于无早发CHD家族史儿童 [(1.34±0 .5 8) ,(1.79± 0 .87)mmol/L]及对照组 [(0 .84± 0 .4 3) ,(0 .96± 0 .87)mmol/L]。有早发CHD家族史者LDL C/HDL C(2 .85± 1.2 1)高于无早发家族史组 (1.37± 1.11)和对照组 (0 .96± 0 .6 8) (P均 <0 .0 1) ,HDL C水平 [(1.11± 0 .2 6 )mmol/L]低于无早发家族?
Objective To study the changes of lipid trigone in children with a family history of coronary heart disease (CHD). Methods The concentrations of plasma low density lipoprotein cholesterol (LDL C), high density lipoprotein cholesterol (HDL C) and triglyceride (TG) were determined in 83 children with a family history of CHD and 83 normal controls. Results Compared with the controls, the levels of TG and LDL C, and the ratio of LDL C/HDL C were higher [( 1.46 ± 0.63 ) mmol/L vs ( 0.84 ± 0.43 ) mmol/L; ( 2.09 ± 1.13 ) mmol/L vs ( 0.96 ± 0.87 ) mmol/L; ( 1.71 ± 1.29 ) vs ( 0.96 ± 0.68 )], and the HDL C level was lower [( 1.48 ± 0.48 ) mmol/L vs ( 1.72 ± 0.53 ) mmol/L]in children with a family history of CHD (all P< 0.01 ). There was no difference in blood lipid trigone between boys and girls with a family history of CHD. The levels of TG and LDL C [( 1.86 ± 0.63 ) and ( 3.12 ± 1.32 ) mmol/L], and the ratio of LDL C/HDL C ( 2.85 ± 1.21 ) were higher in children with a family history of premature CHD than those in children with a family history of non premature CHD [( 1.34 ± 0.58 ) mmol/L, ( 1.79 ± 0.87 ) mmol/L, ( 1.37±1.11 ),[JP] respectively]; and the HDL C level was lower ; and the HDL C level was lower [( 1.11 ± 0.26 ) mmol vs ( 1.59 ± 0.47 )](all P< 0.01 ). The incidence of abnormal lipid trigone in children with a family history of premature CHD or non premature CHD and the controls were 52.6% , 10.9% and 1.2% , respectively. A significant difference was noted among the three groups (P< 0.01 ). Conclusions Lipids metabolism is abnormal in children with a family history of CHD; and more remarkable disorders may be found in those with a family history of premature CHD. In children with a family history of CHD, abnormal lipid metabolism is an obvious high risk index for developing CHD in later life.
出处
《中国当代儿科杂志》
CAS
CSCD
2002年第6期459-461,465,共4页
Chinese Journal of Contemporary Pediatrics
