摘要
目的 :观察文拉法辛治疗抑郁症的疗效、不良反应、耐受性。方法 :选择符合抑郁症诊断标准的抑郁症患者6 4例 ,随机分成A、B两组。A组采用文拉法辛治疗 ,B组采用阿米替林治疗 ,两组初始剂量均为 5 0mg d ,两周内加至 2 0 0mg d ,固定并维持至研究开始后 6周末。结果 :A组显效率为 6 4 .71% (2 2 34) ,总有效率为 85 .2 4 % (2 9 34) ;B组显效率为 6 3.33% (19 30 ) ,总有效率为 86 .6 6 % (2 6 30 ) ,无显著性差异 (P >0 .0 5 )。A组不良反应较B组少而轻 ,有显著性差异 (P <0 .0 5 )。结论 :文拉法辛是一种有效、耐受性好、安全的抗抑郁药。
Objective:To determine the efficacy, side effects, safety, and tolerability of Venlafaxine. Methods: 64 cases of patients with depression were divided into 2 groups randomly. Group A,as test group, was treated with venlafaxine at initial dose of 50 mg/d and up to 200 mg/d within 2 weeks. Group B was treated with amitriptyline at initial dose of 50 mg/d to 200 mg/d within 2 weeks too. The curative effect and side effect were observed after 6 weeks.Results:The total curative rates were 85.24% (29/34) in Group A and 86.66(26/30)in Group B without significant difference between them. There were, however, a significant less side effects in Group A than in Group B.Conclusion:Venlafaxine, an effective antidepressants, has less side effects, more safety and tolerability, compared with amitriptyline.
出处
《江西医学院学报》
2002年第6期30-32,共3页
Acta Academiae Medicinae Jiangxi
