摘要
目的 探讨As2O3对小鼠H22肝癌细胞增殖的抑制作用。方法 建立小鼠H22肝癌实体型移植瘤模型,腹腔应用As2O3治疗后,通过PCNA及CyclinD1免疫组化检测指标反映细胞增殖改变。结果 As2O3能够下调PCNA及CyclinD1蛋白的表达。结论 As2O3对小鼠肝癌细胞的增殖具有明显的抑制作用,具有治疗肝癌潜在价值。
Objective To explore the inhibition of proliferation by arsenic trioxide(As2O3) in mice liver cancer. Methods Mice bearing H22 solid liver cancer cells were treated with defferent density arsenic triox-ide. PCNA and CyclinD1 of tumor cells were studied by immunohistochemical methods. Results PCNA and CyclinD1 positive cells of As2O3 - treated groups were obviously lower than those of controls. Conclusion Animal experiment proved that As2O3 can obviously inhibit the proliferation of mice H22 liver cancer cells.
出处
《哈尔滨医药》
2003年第1期3-4,共2页
Harbin Medical Journal
