摘要
目的:本文旨在探讨两种方法静脉注射异舒吉(ISDN)治疗冠心病心力衰竭的治疗效果。方法:64例心功能Ⅲ级或Ⅳ级的冠心病心力衰竭患者在强心、利尿等常规治疗的基础上,随机分为两组,治疗组:用异舒吉20mg+5％葡萄糖30ml,微量泵静脉泵入5～8ml/h,按此剂量持续给药48h,之后改为异舒吉20～30mg+5％葡萄糖250ml静滴,12.5～50μg/min,每日一次,共5天;对照组:从开始就用5％葡萄糖250ml+异舒吉20～30mg静滴,12.5～50μg/min,每日一次,共7天。观察指标包括心功能、心电图、左心室射血分数(LVEF)、二尖瓣快速充盈期和心房收缩期血流速度(E/A)等。结果:经治疗1周后,对比结果表明先持续泵入异舒吉48h组在心功能、心电图、LVEF、E/A总有效率明显优于间断给药组(P<0.05)。结论:先持续静脉泵入异舒吉48h治疗冠心病心力衰竭效果好。
Objective: To investigate the efficacy of continuous intravenous injection of Isoket with the help of a micropump in the treatment of heart failure in patients with coronary heart disease (CHD). Methods: Sixty four CHD patients with heart failure (NYHA class Ⅲ or Ⅳ) were randomly assigned to 2 groups. Patients of treatment group (n = 32) were given continuous Ⅳ injection of Isoket(20mg in 30ml of 5% glucose, 5-8ml/h) with the help of a micropump for 48 hours and then switched to Ⅳ dripping of Isoket 20-30mg (in 250ml of 5% glucose) qd for 5 days. While patients of control group (n = 32) received Ⅳ dripping of 20-30mg Isoket qd for 7 days. Evaluations of cardiac function, ECG, LVEF, E/A were carried out before and after treatment. Results: The efficacy of treatment group was better than that of control group (P <0.05). Conclusions: It is more effective to inject Isoket intravenously continuously for 48 hours with the help of micropump in the treatment of heart failure in patients with CHD.
