摘要
目的 研究周剂量紫杉醇联合低剂量氟脲嘧啶持续滴注及低剂量顺铂治疗晚期食管癌的近期疗效和毒副反应。方法 晚期食管癌 46例 ,紫杉醇 60mg/(m2 ·week) ,静滴 3小时 ,连用 3周 ;5 -FU 2 0 0mg/(m2 ·d) ,持续滴注 ,连用 2 1天 ;PDD 6mg/(m2 ·d) ,静滴 2小时 ,每周 5天连用 3周 ;以上化疗方案每 4周重复。结果 总有效率 67% ,其中CR 0例 ,PR 31例 ,化疗中主要毒性反应表现为骨髓抑制、消化道反应、脱发等 ,神经毒性、过敏反应少 ,患者耐受性好。结论 紫杉醇作为一种新型抗肿瘤药 ,周剂量使用与低剂量 5-FU持续滴注及低剂量PDD联合 ,对晚期食管癌近期效果显著 ,毒性反应小 。
Objective Observe the clinical efficacy and adverse effects of weelkly dose of Paclitaxel combined with low dose of 5-FU continuous infusion via micro pump and low dose of PDD for the treatment of patients with advanced esophageal cancer.Methods Of 46 patients with advanced esophageal cancer,Paclitaxel 60 mg/m 2 plus 0.9% NS 500 ml for 3 hours on days 1,8,15 were administered by intravenous infusion in conjunction with low dose of 5-FU 250 mg/m 2 by continuous infusion for 21 days and low dose of PDD 6 mg/m 2 plus 0.9% NS 500 ml for 5 days every week until after 3 weeks.The course above was repeated every 4 weeks.The efficacy was evaluated after 2 cycles.Results Overall response rate was 67%,among them,CR was 0 and PR 31.Myelosuppression,alimentary tract reactions,alopecia and neurotoxicity were main toxicities caused by chemotherapy.There was less sensitive reaction and well tolerance.Conclusion Paclitaxel was a novel anticancer drug.There were obvious clinical efficacies and less adverse effects in the treatment of patients with advanced esophageal cancer while weekly dose of Paclitaxel combined with low dose of 5-FU continuous infusion and low dose of PDD were administered.Further study should be carried out.
出处
《河南肿瘤学杂志》
2003年第2期103-105,共3页
Henan Journal of Oncology
关键词
紫杉醇周剂量
氟脲嘧啶持续滴注
低剂量
顺铂
晚期食管癌
weekly dose paclitaxel
5-FU continuous infusion
low dose
PDD
advanced esophageal cancer
