摘要
目的 :对慢性乙型肝炎HBeAg和HBsAg的远期转阴率进行研究 ,为其预后判断和药物疗效的评估提供佐证。方法 :采用回顾性的方法随访 12 0例 6～ 18年前经肝穿病理组织学诊断的慢性乙型肝炎HBeAg和HBsAg的远期转阴率。 结果 :HBeAg转阴 79/ 82例 (96 .34% )。HBsAg转阴 17/ 12 0例 (14 .17% )。Cox回归分析 ,LAK细胞、阿糖腺苷、干扰素治疗均有利于HBeAg转阴 ,病情稳定有利于HBsAg转阴。但 χ2 分析 ,干扰素等抗病毒治疗组与未抗病毒治疗组的转阴率无显著差异。结论 :慢性乙型肝炎HBeAg的远期自然转阴率高 ,HBsAg自然转阴率低。
Objective: To investigate the long-term clearance rate of HBeAg and HBsAg in chronic hepatitis B to evaluate its long-term outcome,and the antiviral drug efficacy. Methods: 120(mean age 31.53±7.52,male/female 96/24) cases of biopsy-proven chronic hepatitis B were followed up.The follow-up time was 11.77±3.75 years.The study focused on long-term clearance rate of HBeAg and HBsAg. Results: The clearance rate of HBeAg and HBsAg were 96.34% and 14.17%,respectively.Ara-A,LAK cell and interferon were of benefit to clear up HBeAg.Sustained normal serum aspartate aminotransferase level was of benefit to clear HBsAg,but the long-term clearance rate of HBeAg and HBsAg were not statistically different compared to those without antiviral therapy by χ 2 analysis. Conclusion: The long-term natural clearance rate of HBeAg in chronic hepatitis B is high,but HBsAg is low.
出处
《重庆医科大学学报》
CAS
CSCD
2003年第2期169-171,共3页
Journal of Chongqing Medical University
基金
中国青年肝病科研基金
