摘要
为探讨苦参补中健胃及防治胃肠疾患的药理基础,本文利用小肠炭末推进试验及盐酸—乙醇所致急性胃损伤模型,对苦参甲醇提取物及其所含成分Kurarinone和Norkurarinone进行了研究。结果证明,苦参甲醇提取物、Kurarinone及Norkurarinone经口灌胃给药均能增强小鼠小肠推进功能,防治盐酸—乙醇所致大鼠急性胃粘膜损伤。
The effects of the methanol extract of Radix Sophora Flavescens and its constituents—kurarhinoe and norkurarinone were investigated by using the test of charcoal meal transport and the model of HC1-ethanol-induced acute gastric lession. Oral administration of the extract at 75mg/kg, 150mg/kg and 250mg/kg, or kurarinone at 50mg/kg, or norkurarinone at 12.5mg/kg, 25mg/kg and 50mg/kg, facilitated the transportation of charcoal meal in mice; the extract at 250mg/kg and 500mg/kg, or kurarinone and norkurarinone at 50mg/kg, prevented and treated the acute gastric lession. The effects may be part of the pharmacological basis of Radix Sophora Flavescens for tonifying the middle jiao to prevent and treat some gastrointestinal diseases.
关键词
苦参
分析
胃粘膜
药理学
SOPHORA FLAVESCENS/anal
SOPHORA FLAVESCENS/pharm
INTESTINE
SMALL/drug eff
GASTRIC MUCOSA/drug eff
STOMACH ULCER/drug ther
