摘要
为观察冠心病患者及冠心病合并糖尿病患者血清糖化低密度脂蛋白 (Gly LDL)指数的变化 ,对 68例 (合并糖尿病 2 8例 ,无糖尿病 40例 )冠心病患者和 2 9例对照者 ,采用氯化硝基四氮唑蓝还原比色法测定Gly LDL指数。结果 :冠心病组的Gly LDL指数较对照组明显增高 (P <0 .0 1 ) ;糖尿病冠心病组Gly LDL指数高于非糖尿病冠心病组(P <0 .0 5 )。结果提示 :冠心病患者Gly LDL增高 ,糖尿病合并冠心病者增高更明显 ;Gly LDL可能是促进糖尿病动脉粥样硬化发生和发展的一个因素 ,并可能作为糖尿病合并大血管并发症的间接指标之一。
The objective of the study was to observe the changes of glycosylated low density lipoprotein (Gly LDL) in patients with coronary artery disease (CAD) and in patients with CAD complicated type 2 diabetes mellitus. The levels of Gly LDL index were measured by nitroblue tetrazolium reduction technique in sixty eight patients with CAD. Among patients with CAD, there were twenty eight patients with type 2 diabetes mellitus and forty patients without diabetes mellitus. The levels of Gly LDL index were significantly higher in patients with CAD than those without CAD ( P < 0.01 ). Among the CAD group, the levels of Gly LDL index were higher in patients with type 2 diabetes mellitus than those in patients without diabetes mellitus ( P <0.05). The result indicates the levels of Gly LDL index increase in patients with CAD and they have a significant increase in patients with CAD complicated type 2 diabetics. Gly LDL may be one cause of the accelerated atherogenesis in type 2 diabetic patients and may be indirect biochemical marker of the development of macroangiopathy in type 2 diabetic patient.
出处
《首都医科大学学报》
CAS
2003年第1期47-50,共4页
Journal of Capital Medical University
关键词
冠心病
糖尿病
糖化低密度脂蛋白
coronary artery disease
diabetes mellitus
glycosylated low density lipoprotein
