摘要
应用酶联免疫反应(ELISA)方法,检测了广西地区368例临床各类肝病病人血清的丙型肝炎病毒抗体(抗HCV)。结果表明,各类肝病的抗HCV阳性率为38.3,％。在急肝、慢迁肝、慢活肝、重肝、肝硬化和肝癌中,抗HCV阳性率分别为15.8％(3/19)、23.1％(6/26)、21.2％(7/33)、37.5％(3/8)、44.4％(28/63)和42.9％(94/219)。抗HCV阳性率有随肝病慢性化而增高的趋势,肝硬化和肝癌的抗HCV阳性率明显高于急性或慢性肝炎患者(P<0.005),且发现HBsAg阴性肝病者的抗HCV阳性率明显高于HBsAg阳性患者。对肝癌患者的调查分析表明,HCV和HBV感染在性别、城乡、民族、文化水平等人群特征分布一致。抗HCV阳性的肝癌患者平均年龄较HBsAg阳性患者高11岁左右。
Elisa was used to detect anti HCV antibodies in 368 serum samples from patients with various types of liver diseases in Guangxi.Epidemiologic analysis was also performed in 219 patients with HCC.Among these 368 patients,anti-HCV positive rate was 15.8%(3/19)in acute hepatitis, 23.1%(6/26)in chronic persistent hepatitis,21.2%(7/33)in chronic active hepatitis,37.5%(3/8) in severe hepatitis,44.4%(28/63)in liver cirrhosis and 42.9%(94/219)in HCC.Anti-HCV positive rate in liver cirrhosis and HCC were significantly higher than that of acute or chronic hepatitis.Simulta- neous HBV-HCV infections did exist in our samples.Anti-HCV positive rate in HBsAg-negative patients was significantly higher than that in HBsAg-positive patients.In HCC patients,the epidemiologic charac- teristics of HCV infection was similar to that of HBV infection(in sex,race,cultural degree,rural or ur- ban etc.Anti-HCV positive HCC patients were approximately 11 years older than those who were HBsAg- positive(48.9±12.1 V.S 37.2±11.5).
关键词
丙型肝炎
病毒
病毒抗体
血清学
hepatitis C virus
anti-HCV
hepatitis
liver cirrhosis
hepatocellular carcinoma
