摘要
目的 评价131碘治疗巨大甲状腺肿性Graves病的效果和个体化的剂量估算方法。方法 2 5 0例巨大甲状腺肿性Graves病患者 ,甲状腺重量 113 .0± 3 9.2 (90～ 45 0 ) g。据患者个体因素 ,确定每克甲状腺组织131碘剂量的范围一般为 2 .775～ 5 .18MBq/g。随访时间 15 .9± 9.9(3～ 44 .7)个月。 结果 一次131碘治疗后 ,15 4例(61.6% )甲状腺功能恢复正常 ,5 3例 (2 1.2 % )甲状腺功能亢进症 (甲亢 )仍持续 ,43例 (17.2 % )发生甲状腺功能减退症 (甲减 ) ;一次131碘治疗后 2 19例 (87.6% )肿大的甲状腺恢复正常。结论 131碘对巨大甲状腺肿性Graves病有效 ;
Objective To evaluate the treatment effects of Graves disease with large goiter treated with 131 I and the method of 131 I individualized estimated dose. Methods Two handred and fifty patients with Graves disease with large goiter(mean of thyroid weight 113.0±39.2g;range 90～450g)were studied according to patient individual factors,the dose per g thyroid tissue ranging from 2.775～5.18MBq/g was determined,then the administered dose was calculated using the special formula.The follow-up was for 15.9±9.9 (range 3～44.7)months. Results After one dose of 131 I,154patients (61.6%) became euthyroid,53 patients(21.2%) remained to be hyperthyroidism,43 patients (17.2%) became hypothyroidism.Large goiter in 219 patients(87.6%) was nomalized. Conclusions Treatment with 131 I is an effective method for Graves disease with large goiter;According to factors affecting outcome,employing the method of individualized radioiodime therapy can improve the efficacy of 131 I treatment.
出处
《苏州大学学报（医学版）》
CAS
2003年第1期63-66,共4页
Suzhou University Journal of Medical Science
