摘要
目的 探讨低剂量顺铂 (LD DDP)、口服甲酰四氢叶酸钙 (CF)及优福定 (UFT)联合治疗转移性结直肠癌的客观疗效及毒性反应。方法 随机用LD DDP、口服CF及UFT治疗方案 (PLU方案 )与静脉CF及 5 氟尿嘧啶 ( 5 Fu)治疗方案 (LF方案 )治疗未曾化疗的转移性结直肠癌 61例 ,其中PLU组 3 0例 ,LF组 3 1例。结果 PLU组和LF组的有效率分别为 3 3 .3 % ( 10 / 3 0 )及 19.4% ( 6/ 3 1) ,两组有效率统计差别无显著性 (P >0 .0 5 )。PLU组的中位生存期为 11.2个月 ,LF组为 10 .3个月 ,两组的中位生存期亦无显著差别 (P >0 .0 5 )。口腔粘膜炎、血白细胞减少的发生率PLU组都较LF组低 (P <0 .0 5 ) ;恶心呕吐、腹泻及血小板减少的发生率PLU组与LF组相近 (P >0 .0 5 )。两组发生的毒性反应大多数为Ⅰ～Ⅱ度 ,LF组各项≥Ⅲ度的毒性反应率之和较高 (P <0 .0 5 )。结论 PLU方案一线治疗转移性结直肠癌近期疗效较佳、相对安全 ,应用也方便 。
Objective To assess the antitumor efficacy and toxicity of the combination of low dose Cisplatin(LD?DDP),oral Leucovorin(CF) and Uracil-Ftorafur(UFT)(the PLU regimen) in patients with metastatic colorectal carcinoma.Methods 61 patients with matastatic colorectal carcinoma were randomly treated with the PLU regimen or the combination of Leucovorin and Fluorouracil(5?Fu)(the LF regimen or the control group).Results The response rate was 33.3%(10/30) for the PLU regimen and 19.4%(6/31) for the LF regimen respectively.There was no statistical difference(P>0.05) between two groups.The median survival time was 11.2 months for the PLU and 10.3 months for the LF.There was no statistical difference(P>0.05) between them,too.The incidense of mucositis and leukopenia in the PLU was lower than that in the LF(P<0.05).The incidence of nausea/vomiting,diarrhea and thrombocytopenia was similar(P>0.05) between the PLU and the LF.Most of the toxicities were mild or moderate.No patient occurred gradeⅣ toxicity in the PLU and the sum of all grade Ⅲ～Ⅳ toxicity rates was higher in the LF than in the PLU(P<0.05).Conclusion The PLU regimen seems to be an effective,safe and convenient first-line treatment for metastatic colorectal carcinoma.
出处
《同济大学学报（医学版）》
CAS
2003年第1期46-48,53,共4页
Journal of Tongji University(Medical Science)
关键词
结直肠肿瘤
化学疗法
联合治疗
colorectal neoplasms
chemotherapy
combined therapy
