摘要
目的 :探讨高脂血症患者血管内皮舒张功能障碍的相关因素。方法 :采用高分辨率超声技术 ,对 62例高脂血症患者血管内皮舒张功能进行检测 ,同时测空腹血糖、纤维蛋白原、C 反应蛋白、超氧化物歧化酶及丙二醛的变化 ,服普罗布考 0 5 g ,每日 2次 ,4周后再次复查血管内皮舒张功能 ,分析治疗前后内皮依赖性舒张功能 (FMD)与各指标间的关系。结果 :①FMD与肱动脉内径的基础值、空腹血糖、纤维蛋白原及超氧化物歧化酶呈显著负相关 (r分别为 -0 495、-0 780、-0 410和 -0 415 ,P分别 <0 0 1、0 0 1、0 0 5和 0 0 5 )。②FMD的改善程度与治疗前的FMD呈显著正相关(r =0 764 ,P <0 0 1) ,与空腹血糖、纤维蛋白原、C 反应蛋白呈显著负相关 (r分别为 -0 660、-0 5 65和 -0 43 0 ,P分别 <0 0 1、0 0 1和 0 0 5 )。结论 :高血脂、血糖、纤维蛋白原及C 反应蛋白为致FMD障碍的危险因子。
Objective:To investigate the risk factors of endothelial relaxing dysfunction in patients with hyperlipidemia.Methods: With high resolution ultrasound technique,the flow mediated dilatation (FMD) and non flow mediated dilatation (after sublingual administration of glyceryl trinitrate) were measured before and after 4 weeks of probucol administration in 62 patients with hyperlipidemia.Fasting plasma glucose,fibrinogen,C reactive protein,superoxide dismutase and malondialdehyde were detected at the same time.The correlated analysis was carried out of FMD and all the markers.Results:①FMD was negatively associated with the diameter of brachial artery at rest,the levels of fasting plasma glucose,fibrinogen and superoxide dismutase ( r =-0 495,-0 780,-0 410,-0 415; p <0 01,0 01,0 05 and 0 05,respetively).②The change of FMD was positively correlated with the baseline of FMD ( r =0 764, p <0 01),and negatively associated with the levels of fasting plasma glucose,fibrinogen and C reactive protein ( r =-0 660,-0 565,-0 430; p <0 01,0 01 and 0 05,respetively).Conclusion: Hyperlipidemia,hyperglycemia,C reactive protein and fibrinogen may be the risk factors and responsible for the pathogenesis of endothelial function impairment.
出处
《中国循环杂志》
CSCD
北大核心
2003年第1期43-45,共3页
Chinese Circulation Journal
