摘要
目的探讨血浆溶血卵磷脂(LysoPC)水平对短暂性脑缺血发作(TIA)后早期发生脑卒中的预测价值。方法选取2015年3月至2018年2月就诊于该院急诊科或神经内科的TIA症状发作24h内就诊患者293例进行评估,采用酶联免疫吸附试验测定患者血浆LysoPC水平。随访3个月内发生脑卒中者列入观察组,未发生脑卒中者列入对照组。采用SPSS19.0软件进行统计分析,比较两组血浆LysoPC变化,受试者工作特征曲线(ROC曲线)分析LysoPC诊断TIA后早期发生脑卒中的临床价值。结果 293例TIA患者中35例早期发生脑卒中,其血浆LysoPC水平显著高于对照组,两组差异有统计学意义(P<0.05)。ROC曲线分析显示,观察组血浆LysoPC曲线下面积(AUC)为0.836;LysoPC最佳截断值为51.26mol/L,灵敏度为0.683,特异度为0.879。结论血浆LysoPC水平对TIA后早期发生脑卒中有较好的预测价值,可在临床推广。
Objective To discuss the predictive value of plasma lysophosphatidylcholine(LysoPC)for stroke recurrence after transient ischemic attack(TIA).Methods A total of 293cases of TIA patients admitted to Chongqing Jiulongpo People′s Hospital were investigated from March 2015to February 2018.After three months,patients who had stroke recurrence were divided into observation group,while,who had no stroke recurrence were divided into control group.Plasma LysoPC were detected by adopting the enzymelinked immunosorbent assay.The data were analyzed using SPSS19.0,differences of plasma LysoPC between the two groups were evaluated.A receiver operating characteristic(ROC)curve was constructed to calculate the area under the curve(AUC)of LysoPC.The sensitivity and specificity for the cut-points were calculated as well as to estimate the accuracy of the diagnosis.Results Level of LysoPC of strokeⅠpatients was significantly higher than that of control group(P<0.05).ROC analysis showed that cut-off value of plasma LysoPC was 51.26mol/L,and the AUC was 0.836.The sensitivity and specificity were 0.683and 0.879respectively.Conclusion Plasma levels of LysoPC are reliable in predictive for stroke recurrence after TIA,which is worthy of promotion.
作者
李佳蓓
张云兰
李然梅
曹冠柏
LI Jiabei;ZHANG Yunlan;LI Ranmei;CAO Guanbai(Department of Emergency,Jiulongpo People′s Hospital,Chongqing400051,China)
出处
《检验医学与临床》
CAS
2019年第6期755-757,共3页
Laboratory Medicine and Clinic
基金
重庆市九龙坡区科学技术委员会科技计划项目(2015-12)
