摘要
目的 探讨乙型肝炎重叠庚型肝炎病毒 (HGV)感染的状况及庚型肝炎病毒对乙肝患者的影响。方法 采用逆转录聚合酶链反应 (RT -PCR)检测 165例乙肝患者和 160例健康人血清中的HGV -RNA及检测乙肝重叠HGV感染患者及单纯乙肝患者的抗HBc-IgM、HBV -DNA、HBeAg ,比较其临床症状和体征的差异。 结果 HGV在乙肝患者的感染率为 14 5 % ,高于健康人感染率 1 9% (P <0 0 0 1) ;HGV在各型乙肝及肝硬化患者中的阳性率相似 (P >0 0 5 ) ;乙肝重叠HGV感染者及单纯乙肝患者病毒复制指标抗 -HBc -IgM ,HBV -DNA ,HBeAg以及肝功能 ,临床症状及体征比较无显著性差异 (P >0 0 5 )。结论 HGV在乙肝患者中的感染率比健康人高 ;HGV对HBV的复制无影响 ,并且HGV不会加重乙肝患者肝脏损害和临床症状 ;
Objective To investigate the infective state of hepatitis B patients who superinfected with HGV and the effect of HGV on hepatitis B patients.Methods Reverse transcription polymerase chain reaction technique(RT-PCR) was used to determine HGV-RNA in the serum of 165 hepatitis B patients and 160 healthy persons;HBc-IgM?HBV-DNA and HBeAg were measured and the difference of clinical symptoms and signs were compared between hepatitis B superinfectecd with HGV and patients with hepatitis B alone.Results The infection rate of HGV in heptitis B patients was 14.5%,which was higher than that of 1.9% in healthy population(P<0.001).There were no significant differences in anti-HBc-IgM,HBV-DNA,HBeAg and liver function as well as clinical symptoms and signs between hepatitis B patients superinfected with HGV and patients with hepatitis B alone(P>0.05).Conclusion The infection rate of HGV in hepatitis B patients was higher than that in healthy population;HGV had no effect on the replication of HBV,which did not aggravate liver injury and clinical symptoms in hepatitis B patients.HGV did not accelerate the development of hepatitis B and cirrhosis.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2003年第3期269-270,共2页
Chinese Journal of Public Health
