摘要
目的 探讨儿童肾移植手术技巧及术后免疫抑制剂的应用特点 ,提高人 /肾存活率。 方法 分析 2 6例儿童肾移植患者的手术、免疫抑制剂使用和长期存活情况等临床资料。 结果 移植肾功能延迟恢复 2例 ,急性排斥反应 (AR) 11例 ,慢性排斥反应 10例 ,1例肾移植 2周后发生复发性肾炎 ,病理显示为局灶性节段性肾小球硬化 ,治疗后肾功能尚可维持 ;1、3、5年人 /肾存活率分别为96% / 88% ,92 % / 73 %和 88% / 62 % ,总死亡率 12 %。 结论 良好的组织配型、适宜的手术方法。
Objective To report our experience in surgical technique of pediatric renal transplantation and administration of immunosuppressive agents for improvement of recipient/graft survival. Methods Twenty six pediatric recipients (less than 18 years) received cadaveric renal allografts between June 1980 and March 2001.A retrospective analysis was made in these 26 cases with respect to the technical consideration of transplant,immunosuppressive regimens and long term survival. Results Two cases (8%)had delayed graft function,11(42%)had acute rejection and 10 (38%)had chronic rejection.One case develo ped recurrent nephritis,which was pathologically confirmed to be focal segment glomerulosclerosis (FSGS).The recipient/graft survival rates of 1,3,5 years were 96%/88%,92%/73% and 88%/62% respectively,with mortality of 12%. Conclusions In pediatric renal transplantations,good tissue matching,appropriate technique of vessel anastomosis,early diagnosis of acute rejection and optimal adjust ment of blood level for immunosuppressants are keys to success.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2003年第3期188-190,共3页
Chinese Journal of Urology
关键词
肾移植
儿童
存活
Kidney transplantation
Child
Survival
