摘要
目的探讨乙型肝炎肝硬化患者门静脉压力梯度(PPG)与肝静脉压力梯度(HVPG)间相关性及其临床价值。方法收集2016年6月至2017年12月在南方医科大学南方医院接受经颈静脉肝内门体分流术(TIPS)乙型肝炎肝硬化患者肝静脉楔入压(WHVP)、肝静脉游离压(FHVP)、下腔静脉压(IVCP)、门静脉压(PVP)资料,同时计算HVPG和PPG,Spearman秩和检验分析WHVP与PVP、FHVP与IVCP、HVPG与PPG相关性。结果 17例患者符合入组条件,平均WHVP、PVP分别为(25.88±6.40) mmHg、(27.65±6.20) mmHg,两者呈正相关(r=0.914,P<0.01),斜率为0.883;平均FHVP、IVCP分别为(7.24±2.80) mmHg、(7.76±2.90) mmHg,两者呈正相关(r=0.815,P<0.01),斜率为0.847;平均HVPG、PPG分别为(18.65±6.60) mmHg、(19.94±6.56) mmHg,两者呈正相关(r=0.875,P<0.01),斜率为0.868。结论乙肝后肝硬化患者HVPG与PPG、WHVP与PVP、FHVP与IVCP有较好相关性,临床上可用HVPG反映乙肝后肝硬化患者PPG。
Objective To investigate the correlation between portal pressure gradient(PPG) and hepatic venous pressure gradient(HVPG) in patient with hepatitis B cirrhosis, and to discuss its clinical value. Methods A total of 17 patients with hepatitis B cirrhosis, who received transjugular intrahepatic portosystemic shunt(TIPS) treatment during the period From June 2016 to December 2017 at Nanfang Hospital of Southern Medical University, China, were enrolled in this study. The related data, including wedge hepatic venous pressure(WHVP), free hepatic venous pressure(FHVP), inferior vena cava pressure(IVCP) and portal venous pressure(PVP), were collected. HVPG and PPG were calculated. Spearman rank sum test was used to analyzed the correlations between WHVP and PVP, between FHVP and IVCP, and between HVPG and PPG. Results Seventeen patients matched the inclusion criteria. The mean WHVP and PVP were(25.88 ±6.40) mmHg and(27.65 ±6.20) mmHg respectively, and a parallel relationship existed between WHVP and PVP(r=0.914, P<0.01), with the slope being 0.883. The mean FHVP and IVCP were(7.24±2.80) mmHg and(7.76±2.90) mmHg respectively, and a positive correlation existed between FHVP and IVCP(r=0.815, P<0.01), with a slop of 0.847. The mean HVPG and PPG were(18.65±6.60) mmHg and(19.94±6.56) mmHg respectively, and HVPG and PPG were positively correlated(r=0.875, P<0.01), the slop was 0.868. Conclusion In patients with hepatitis B cirrhosis, significant correlation exists between HVPG and PPG, between WHVP and PVP, and between FHVP and IVCP. Clinically, HVPG can be used to estimate PPG in patients with hepatitis B cirrhosis.
作者
林志鹏
陈斯良
赵剑波
LIN Zhipeng;CHEN Siliang;ZHAO Jianbo(Department of Interventional Radiology,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong Province 510515,China)
出处
《介入放射学杂志》
CSCD
北大核心
2019年第2期120-123,共4页
Journal of Interventional Radiology
关键词
肝硬化
门静脉高压症
经颈静脉肝内门体分流术
肝静脉压力梯度
门静脉压力梯度
cirrhosis
portal hypertension
transjugular intrahepatic portosystemic shunt
hepatic venous pressure gradient
portal pressure gradient
