摘要
目的:探讨多塞平联合质子泵抑制剂(PPI)三联疗法治疗伴有抑郁的幽门螺杆菌(Hp)相关慢性胃炎的临床疗效。方法:选取2015年4月至2017年6月本院收治的伴有抑郁的Hp相关慢性胃炎患者92例,采用回顾性分析法分析所有患者的临床及随访资料,根据资料中的治疗方法将92例患者分为对照组和研究组各46例,对照组予以PPI三联疗法(兰索拉唑肠溶胶囊+阿莫西林胶囊+克拉霉素胶囊)治疗,研究组在对照组的基础上加用多塞平片治疗,两组患者均治疗4周,治疗结束后观察比较两组患者的临床疗效、HP根除率及焦虑、抑郁改善情况,并记录两组患者在治疗过程中不良反应发生情况。结果:①研究组临床治疗总有效率(95.65%)明显高于对照组(80.43%),差异具有统计学意义(χ~2=5.059,P=0.024);②研究组HP根除率(91.30%)明显高于对照组(73.91%),差异具有统计学意义(χ~2=3.903,P=0.048);③研究组患者治疗后其SAS、SDA评分明显低于对照组,差异具有统计学意义(t=3.097,P=0.002;t=6.235,P<0.001);④研究组药物不良反应发生率(10.87%)明显低于对照组(32.61%),存在显著差异(χ~2=6.389,P=0.110)。结论:多塞平联合PPI三联疗法治疗伴有抑郁的Hp相关慢性胃炎患者临床疗效显著,可减轻焦虑、抑郁程度,明显提高HP根除率,减少药物不良反应发生,可在临床上推广应用。
Objective:To investigate the clinical efficacy of the combination of doxepin and proton pump inhibitor(PPI)in the treatment of chronic gastritis associated with Helicobacter pylori(Hp).Methods:From April 2015 to June 2017,92 patients with Hp-related chronic gastritis with depression in our hospital were selected as the study.The clinical and follow-up data of all patients were analyzed by retrospective analysis.According to the data in the treatment they were divided into control group and study group,each 46 cases.The control group was treated with PPI triple therapy(lansoprazole enteric-coated capsules+amoxicillin capsules+clarithromycin capsules),and the study group was treated with doxepin on the basis of the control group.Both groups were treated for 4 weeks.After treatment,the clinical efficacy,HP eradication rate,improvement of anxiety and depression were observed and compared between the two groups.The occurrence of adverse reactions in the two groups were recorded.Results:①The total clinical effective rate(95.65%)in the study group was significantly higher than that in the control group(80.43%).The difference was statistically significant(χ~2=5.059,P<0.05).② The study group’s HP eradication rate(91.30%)was significantly higher than the control group(73.91%),the difference was statistically significant(χ~2=3.903,P<0.05).③ SAS and SDA scores of the study group were significantly lower than those of the control group after treatment(t=3.097,6.235;P<0.01).④The adverse drug reaction rate(10.87%)in the study group was significantly lower than that in the control group(32.61%)(χ~2=6.389,P<0.05).Conclusion:The combination therapy of doxepin and PPI has significant clinical curative effect in the treatment of patients with Hp-associated chronic gastritis associated with depression,which can reduce anxiety and depression,significantly improve the eradication rate of HP and reduce the incidence of adverse drug reactions.
作者
苏冠春
SU Guanchun(People's Hospital of Chongqing Banan District,Chongqing648800,China)
出处
《中国健康心理学杂志》
2019年第2期196-199,共4页
China Journal of Health Psychology
关键词
多塞平
PPI三联疗法
慢性胃炎
抑郁
幽门螺杆菌
Doxepin
PPI triple therapy
Chronic gastritis
Depression
Helicobacter pylori
