摘要
目的 观察国产乌司他丁治疗急性胰腺炎的临床疗效及机制探讨。方法 2 5 6例证实急性胰腺炎的病人进入本研究 ,其中乌司他丁组 10 4例 ,对照奥曲肽组 15 2例 ,治疗 5d、7d、10d内分别观察症状、体征及实验室数据变化 ,用 χ2 检验进行统计处理。结果 乌司他丁组的临床症状、体征及实验室数据 ,在治疗前后的变化有显著性差异 (P <0 0 1) ,而治疗后的变化与奥曲肽组相比 ,差异无显著性 (P >0 0 5 ) ,但治疗组对血、尿淀粉酶的恢复时间较对照组更短 (P <0 0 5 )。结论 国产乌司他丁能明显改善急性胰腺炎病人的症状和体征 ,缩短疗程 ,对急性胰腺炎疗效较好 ,本组总有效率 10 0 % ,痊愈率 80 8% ,且副作用少见。
Objective To investigate the therapeutic effects of domestically manufactured Ulinastatin on acute pancreatitis and explore its mechanism. Methods A total of 256 patients with acute edematic pancreatitis were randomized into the treated group and control group. In the treated group, 104 patients were treated with Ulinastatin. In the control group, 152 patients were treated with Sandostatin. After all the patients were treated for 5, 7 and 10 days, respectively, the changes in symptoms, physical signs and laboratory data were observed. χ 2 test was used for statistical analysis. Results The differences of changes in symptoms, signs and laboratory data after the Ulinastatin treatment were more obvious than those before the treatment (P<0 01). However, there was no significant difference between the treated group and control group (P>0 05). The time for blood and urine AMY recovery was shorter in the treated group than in the control. Conclusions Ulinastatin can greatly relieve the symptoms and signs of acute edematic pancreatitis and shorten its time of treatment. Meanwhile, it has fewer side effects.
出处
《中华肝胆外科杂志》
CAS
CSCD
2003年第3期137-139,共3页
Chinese Journal of Hepatobiliary Surgery
