摘要
目的 探讨一氧化氮 (NO)、内皮素 (ET - 1)在急性有机磷农药中毒 (AOPI)肺水肿形成中的作用。方法 分别用还原Griess法和放免法检测AOPI患者发生肺水肿前、中、后血浆中NO、ET - 1。结果 AOPI患者ET - 1均有所增高 ,且肺水肿时升高最为显著 (P <0 0 1) ,但肺水肿前与对照组比较无显著性差异 (P >0 0 5 ) ;NO肺水肿前显著升高 ,肺水肿时则降低 ,与对照组比较均有显著性差异 (P <0 0 1) ,肺水肿后又有所升高 ,与对照组比较 P <0 0 5。结论 NO的细胞毒性作用及NO合成减少、加剧内皮素的缩血管作用等是AOPI肺水肿形成的重要因素。提示在AOPI肺水肿的治疗过程中 ,给予低浓度的NO吸入必将起到重要作用。
Objective To study the effects of nitric oxide(NO) and endothelin-1(ET-1) on the formation of pulmonary edema in the patients with acute organic phosphorus intoxication(AOPI).Methods Plasma NO and ET-1 were tested with reductive Griess and radioimmuno assay for the AOPI patients before,in and after suffering from pulmonary edema respectively.Results ET-1 was rised in AOPI patients and it was more significant(P<0 01) while suffering from pulmonary edema, there was no significant defference compared with control before pulmonary edema;NO was higher before pulmonary edema,and it was low during pulmonary edema,the change was more significant (P<0 01) after comparing with control.It became higher(P<0 05) after pulmonary edema,and compared with control (P<0 05).Conclusion The cytotoxity and reduction of NO intensified the effects of endothelin on the blood vessels,which was an important factor for the formation of AOPI pulmonary edema.So it would play an important role in AOPI pulmonary edema to inspire low density NO in the process of treatment.
出处
《中国急救医学》
CAS
CSCD
北大核心
2003年第3期133-134,共2页
Chinese Journal of Critical Care Medicine
基金
河南省 2 0 0 0年度科技攻关项目 (No 0 0 1170 63 4)
关键词
一氧化氮
内皮素
急性有机磷农药中毒
肺水肿
Organic phosphorus
Intoxication
Nitric oxide
Endothelin
Pulmonary edema
