摘要
目的 :评价急性心肌梗塞 (AMI)患者及梗塞后在溶栓期间白细胞介素 8(IL - 8)的变化及临床意义。方法 :应用放射免疫分析 (RIA)检测IL - 8水平并与正常对照组比较。结果 :AMI患者血清IL - 8水平明显高于正常对照组 (p<0 0 0 1) ;冠脉再通组IL - 8水平在溶栓后 2h开始升高 ,4h达峰值 ,与冠脉未通组水平有显著性差异 (p <0 0 0 1)。结论 :IL - 8对AMI及AMI静脉溶栓后冠脉再通的诊断有一定价值 ,并提示溶栓后ST段再抬高与缺血 /再灌注IL -
Objective To assess the clinical implication of changes of serum interleukin-8 (IL-8) levels at onset of infarction and during reperfusion in patierts with acute myocardial infarction(AMI). Methods RIA was used ot measure serum IL-8 levels in 30 patients with AMI and 30 controls. Results Serum IL-8 levels in patients with AMI were markedly higher than those in the controls ( p <0 001). The level of IL-8 began to increase at 2 hours after thrombolysis and rose to peak value at 4 hours. There was significant difference in peak concentration between patients with and without successful reperfusion ( p <0 01). Conclusion IL-8 has definite value for diagnosis of AMI occurrence and result of thrombolytic theropy. ST segment reelevation after thrombolysis may be relates to release of IL-8 after coronary artery reperfusion.
出处
《放射免疫学杂志》
CAS
2003年第1期13-14,共2页
Journal of Radioimmanology
关键词
急性心肌梗塞
溶栓疗法
放射免疫分析
白介素-8
acute myocaydial infarction(AMI), thrombolytictherapy, radioimmunoassay(RIA), interleukin-8(IL-8)
