摘要
目的 从肝功能异常患者中筛选自身免疫性肝炎 (AIH)病例 ,并探讨其临床病理表现特征。方法 采用国际自身免疫性肝炎小组 (IAIHG)新修订的描述性诊断标准和计分系统 ,对肝功能异常患者进行筛选 ,对符合诊断的患者进行临床病理特点分析。结果 符合诊断的 13例AIH患者均为女性 ,高发年龄为 4 0～ 6 0岁 ,肝功能生化检查表现为肝炎样改变。 10例表现为高γ球蛋白血症 ,10例 ,IgG高于正常 ,11例抗核抗体 (ANA)阳性 ,1例 pANCA阳性 ,1例抗SLA/LP阳性 ,4例伴发相关的自身免疫性疾病。在有肝穿刺活检组织资料的 5例患者中 ,出现界板性肝炎 5例 ,小叶性肝炎 5例 ,未见玫瑰花结样改变 ,肝纤维化或肝硬化 2例。结论 AIH患者多为中年女性 ,以肝组织活检呈界板性肝炎、血清自身抗体。
Objective To investigate clinical and pathological features of autiimmune hepatitis(AIH) from patients whom had abnormal liver function Methods According to the revised descriptive criteria and scoring system for diagnosis of autoimmune hepatitis proposed by the International Autoimmune Hepatitis Group,we examined the clinical and pathological characteristics of the patients Results All patients(13 cases) diagnosised as AIH were female and most of them were between 40 and 60 years of age Liver fuction test of the patients showed hepatic profile 10 patients(10/13) had hypergammaglobulinemia and elevated serum Ig G level Eleven cases(11/13) are positive for antinuclear antibody(ANA),4 patients(4/13) had concurrent autoimmune diseases Among 5 patients who underwent live biopsy, interface hepatitis and lobular hepatitis were observed in 5 and 5 patients, respectively,liver fibrosis or cirrhosis were detected in 2 patients(2/5) Rosetting of liver cells were not found Conclusion Autoimmune hepatitis is mainly diagnosed in middle aged women, characterized by interface hepatitis on histologic examination,and the presence of circulating autoantibody, hypergammaglobulinemia
出处
《临床和实验医学杂志》
2002年第4期231-233,共3页
Journal of Clinical and Experimental Medicine
