摘要
目的 探讨淋巴细胞计数联合HBV -DNA定量检测在预示重症肝炎趋势、诊断早期重症肝炎及判断预后中的意义。方法 选择初诊慢性乙型肝炎 (中度 ) 65例 ,根据病情最终演变情况分成慢性乙型病毒性肝炎 (重度 )组和重症肝炎组 ,观察两组淋巴细胞计数和HBV -DNA负荷量变化情况。结果 慢性乙型病毒性肝炎 (重度 )组患者中仅有 4例患者血淋巴细胞计数在病情演变中出现低于正常值情况 ,但患者血HBV -DNA负荷量较高。重症肝炎组中 17例患者在病情演变为重症肝炎前血淋巴细胞计数出现低于正常值情况 ,仅 1例患者始终正常 ,但患者HBV -DNA负荷量均为阴性。重症肝炎组和慢性乙型肝炎 (重度 )组淋巴细胞计数平均值分别为 0 .8± 0 .12× 10 9/L和 1.3± 0 .34× 10 9/L ,两组比较有显著差异 (P <0 .0 5 )。 18例重症肝炎患者在淋巴细胞减少平均 7.7± 2 .1天后出现明显重症肝炎临床症状和体征。结论 淋巴细胞计数联合HBV -DNA定量检测有助于预测慢性乙型病毒性肝炎 (中度 )的发展趋势。
Objective To investigate the significance of lymphocyte count and HBV-DNA load in foreboding the trend of severe hepatitis,in diagnosis of early stage of severe hepatitis and prognosis.Methods 65 cases with chronic hepatitis B virus(moderate) were studied.According to development,65 cases were divided into two groups:chronic hepatitis B virus (severe) and severe hepatitis.Lymphocyte count and HBV-DNA load were observed.Results Decrease of lymphocyte count was found in only 4 cases with chronic hepatitis B virus(severe),whereas HBV-DNA load was high all the time in all cases with chronic hepatitis B virus(severe);decline of lymphocyte count was observed in 17 cases of severe hepatitis,only 1 case was normal all the time,but HBV-DNA load was negative in all cases with severe hepatitis.The mean value of lymphocyte in chronic hepatitis B virus(severe) and severe hepatitis is 1.3±0.34×10 9/L and 0.8±0.12×10 9/L,respectively( P <0.05).Conclusion Lymphocyte count and HBV-DNA load contribute to prediction of developmental trend of chronic hepatitis B virus(moderate) and have important significance in diagnosis and prognosis of early stage of severe hepatitis.
出处
《胃肠病学和肝病学杂志》
CAS
2003年第1期49-51,共3页
Chinese Journal of Gastroenterology and Hepatology
