摘要
目的 比较目标剂量的卡维地洛和阿替洛尔治疗稳定劳力型心绞痛的临床效果和安全性。方法 选择运动试验结果阳性的稳定劳力型心绞痛病人 97例 ,按入院先后随机分为治疗组 (卡维地洛组 )和对照组 (阿替洛尔组 )。两组用药均于两周内调整至目标剂量 (心室率 5 5～ 60次 /min) ,然后给予目标剂量治疗 4周。共 86例病人完成试验 ,比较两组治疗前后运动试验主要参数以及心绞痛发作次数和硝酸甘油耗量等指标。结果 两种药物均能增加运动耐量 ,但卡维地洛优于阿替洛尔 (P<0 .0 1～ 0 .0 0 1) ;心绞痛发作次数及硝酸甘油耗量卡维地洛亦优于阿替洛尔 (P<0 .0 5及 P<0 .0 1)。结论 目标剂量的卡维地洛治疗稳定劳力型心绞痛效果优于选择性 β受体阻滞剂阿替洛尔 。
Objective To compare the safety and efficacy of carvedilol and atenolol in the treatment of stable exertional angina. Methods Ninety seven patients with stable exertional angina whose exercise test were positive were enrolled into this study. The patients were randomized into treatment group (carvedilol group) and control group(atenolol group). First, the treatment medication in two groups was titrated to target doses within two weeks. The heart rate ranged from 55 bpm to 60 bpm.Then, the medication was given at target doses for 4 weeks. A total of 86 cases completed the study. main indices of exercise test, frequency of onset of angina pectoris and consumption of nitrates were compared before and after treatment. Results Carvedilol and atenolol could both improve the tolerance of exercise while carvedilol had better effect than atenolol( P <0.01~0.001). There were differences in the reduction of angina times and consumption of nitrates between the two groups. Carvedilol had better effects than atenolol ( P <0.05 and P <0.001). Conclnsion Carvedilol at targeted doses in the treatment of stable exertional angina has better effect and fewer side effects than atenolol
出处
《中国心血管杂志》
2003年第1期29-31,41,共4页
Chinese Journal of Cardiovascular Medicine
