摘要
本文选用ICR小鼠为实验动物,腹腔注射不同剂量^(125)I,研究其对小鼠生殖细胞染色体畸变发生率影响及动态变化规律。实验结果显示:(1)^(125)I染毒(555kBq)后1d染色体畸变率最高,精原细胞和精母细胞染色体畸变率均为1.8％,但畸变率随时间延长而迅速降低。(2)^(125)I染毒后1d,0、175、555及1665kEq各组精原细胞染色体畸变率分别为0.14％、0.45％、1.80％及2.65％;精母细胞染色体畸变率分别为0.13％、0.60％、1.80％及2.20％,经行列X^2检验,各组间差别均有显著意义。本文结果进一步揭示了^(125)I对哺乳动物有潜在的遗传危害。
In this experiments, male of the ICR strain were used and were in-
jected intraperitoneally with different dose of ^(125)I. The rate of chromosomal abnorma-
lities in mouse germ cells, and its changes with time were studied. The results showed
that: (1) From 1 to 28 days after injection of 555 kBq of ^(125)I, the rate of chromo-
somal abnormalities of germ cells reached a peak at 1 day. During that time, the ab-
normal rate in spermatogonias is 1.8%, which is cqual to that in spermatocytes. After
that, the abnormal percentages in those cells were quickly droped down. (2) The ra-
tes of chromosomal aberrations in spermatogonias in males treated with 0,175, 555
and 1665 kBq of ^(125)I at 1 day after injection were 0.14%, 0.45%, 1.80% and
2.65% respectively. Similarly, the chromosomal abnormal rates in spermatocytes were
0.13%, 0.60%, 1.80% and 2.20% accordingly. These results indicate ^(125)I can induce
a significant increase in the percentage of chromosomal aberrations of germ cells in
male treated with ^(125)I. The results also provide further evidence of the cytogenetic ef-
fects to mammalian germ cells of ^(125)I.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
1992年第2期77-80,共4页
Journal of Radiation Research and Radiation Processing
关键词
生殖细胞
碘125
畸变
染毒
^(125)I
Germ cell
Spermatogonia
Spermatocyte
