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美西律、胺碘酮对QT离散度的影响及其临床意义

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摘要 目的 :比较美西律 ( 34例 )和胺碘酮 ( 2 7例 )分别治疗室性心律失常前后QT离散度 (QTd)的变化及复发的影响。方法 :采用随机、单盲方法 ,测定两组病人用药前及用药 2W后的QTd。结果 :①胺碘酮组用药后QT明显延长 ,但QTd反而降低 ( 4 3.8± 1 5 .1 )ms与 ( 33.8± 1 5 .9)ms,P <0 .0 5 ;美西律组用药前后QT及QTd无显著变化 (P >0 .0 5 )。②胺碘酮组与美西律组的有效率分别为 86.2 %和 83.1 %(P >0 .0 5 ) ;停药后一月内的室性心律失常复发率分别为 1 8.5 %和 5 0 % (P <0 .0 5 ) ,美西律组复发者较未复发者的QTd明显延长 ( 4 9.1± 1 4.9)ms与 ( 4 0± 1 2 .6)ms ,P<0 .0 1。结论
出处 《长治医学院学报》 2002年第4期263-264,共2页 Journal of Changzhi Medical College
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