摘要
目的 探讨慢性支气管炎 (以下简称慢支炎 )患者的痰、诱导痰、血清的白细胞介素 (以下简称白介素 )及C反应蛋白 (CRP)在急性发作期及临床控制时的变化关系 ;评价痰、诱导痰、血清白介素 (IL 4、IL 6、IL 8)之间及与CRP之间的相关性。方法 对 30例慢支炎患者急性发作期与临床控制患者的痰、诱导痰、血清IL 4、IL 6、IL 8及CRP进行定量测定。实验室检测及数据统计均采用盲法。结果 ①慢支炎急性发作期患者的痰、诱导痰、血清IL 4、IL 6、IL 8与CRP较临床控制时明显增高 (P <0 0 0 1)。②慢支炎的痰、诱导痰、血清白介素及CRP间的相关性除IL 4的诱导痰与血清外均有显著统计学意义 (P <0 0 0 1)。③临床控制的痰、诱导痰、血清白介素及CRP水平未恢复到参考值及正常值范围内。④痰与诱导痰的相关性最高 (r>0 8834及以上 )。结论 ①气道白介素及血清白介素、CRP增高能反映慢支炎气道的炎性变化。②痰及诱导痰是气道炎性变化的非侵入性检测手段。③白介素有多种调节作用。
Objective To evaluate relations of changes of interleukin and CPR in sputum、induced sputum and serum of patients with chronic bronchitis in acute phase and clinical controlling phase. Methods Sputum、induced sputum and serum interleukin (IL 4,IL 6 and IL 8) and CRP of patients with Chronic bronchitis in acute phase and in clinical controlling phase were tested. Blinded method were adopted in the study. Results 1.The level of sputum, induced sputum and serum interleukin (IL 4,IL 6 and IL 8) and CRP in acute phase were significantly higher than in clinical controlling phase of Chronic bronchitis (P<0.001). 2.There are significantly relationships among sputum、 induced sputum and serum interleukin and CRP in acute phase and in clinical controlling phase except induced sputum and serum IL 4 (P<0.001). 3. Untill clinical controlling. The level of sputum, induced sputum and serum interleukin (IL 4,IL 6 and IL 8) and CRP have not come back to normal. 4.There are the best relation in sputum and induced sputum interleukin (IL 4,IL 6 and IL 8) and CRP (r>0.88) Conclusions 1.The raise of interleukin and serum interleukin may be representative inflammation severity in airway of patients with chronic bronchitis. 2. To measure sputum and induced sputum interleukin and CRP is one of non invade method for inflammation change of airway. 3. Interleukin possess multi modulation function. [
出处
《遵义医学院学报》
2002年第6期510-512,共3页
Journal of Zunyi Medical University
基金
成都铁路局科技项目 (CX974 4 )