摘要
目的:观察抗抑郁治疗对老年不稳定型心绞痛伴抑郁患者近期预后的影响。方法:将老年不稳定型心绞痛伴抑郁的患者随机分为抗抑郁治疗组和对照组各31例,治疗组在常规心脏病药物治疗基础上给予心理治疗及加服抗抑郁药盐酸舍曲林(左洛复)50mg/d,共12周;对照组给予单纯常规心脏病药物治疗。结果:治疗组心肌缺血明显改善,心绞痛复发率及发生急性心肌梗死比率低,与对照组比较,有显著性差异(P<0.05)。结论:抗抑郁治疗能明显改善不稳定型心绞痛伴抑郁患者的近期预后。
Objective: To investigate the influence of antidepressive therapy on short-term prognosis in elderly anginal patients with depression. Methods: Sixty-two unstable anginal patients were randomly assigned to treatment group (n =31) conventioua or control group (n = 31). Patients in the treatment group received psychotherapy and antidepressant sertraline HCl(Zoloft Pfizer) 50mg qd on the basis of conventional cardiac medicinal therapy for 12 weeks; While patients in the control group received only conventional cardiac medicinal therapy. Results: In the treatment group, Myocardial ischemia was more significantly improved and the recurrence rate of angina and incidence of AMI were lower. There were significant differences between the 2 groups(P<0.05). Conclusions: Antidepression measures can significantly improve the short-term outcome of elderly unstable anginal pectoris patients.
