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草酸铂、氟脲嘧啶为主化疗方案治疗晚期消化道肿瘤 被引量:6

Clinical application with oxaliplatin(OXA) and 5-fluorouracil(5-FU)-based chemotherapy in advanced gastrointestinal management carcinoma
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摘要 目的 探讨以草酸铂 (OXA)、氟脲嘧啶 (5 FU)为基础的化疗方案在晚期消化道恶性肿瘤治疗中不同的应用方法。方法  110例治疗方案如下 :1.OXA +5 FU/CF方案 (CF甲酰四氢叶酸 ) ,OXA13 0mg·m-2 静滴d1;CF10 0mg·m-2 ·d-1静滴 2hr,接用 5 FU0 5 g·m-2 ·d-1静滴 6 8hr,d1-5,q3wks ,治疗 3 3例 ;2 .FOLFOX方案 ,OXA13 0mg·m-2 ·d1;CF2 0 0mg·m-2 ·d-1静滴 2hr ,接用 5 FU40 0mg·m-2 ·d-1静推 ,再 5 FU1 6g·m-2 ·d-1持输 2 2小时d1-2 ,q2wks ,治疗 43例 ;3 .OXA +5 FU低剂量长时间持输 ,OXA10 0mg静滴d1,d8,d15;5 FU2 5 0mg·m-2 ·d-1持输 2 1d ,q4wks,治疗 2 3例 ;4.OXA +希罗达 (CAP)方案 ,OXA13 0mg·m-2 静滴d1;希罗达 1g ,一天 2次口服连续 14d ,q3wks,治疗 6例 ;5 .OXHLV5FU3方案 ,即OXA +5 FU/CF加羟基喜树碱 (HCPT ) ,OXA13 0mg·m-2 静滴d1;CF2 0 0mg·m-2 ·d-1静滴 2hr,接用 5 FU40 0mg·m-2 ·d-1静推 ,再 5 FU1 6g·m-2 ·d-1持输 2 2hr,d1-3;HCPT10mg·d-1,d1-5,q3wks,治疗 5例。 结果 各方案的总有效率 (CR +PR)分别为 3 0 3 %(10 / 3 3 ) / 5 1 2 % (2 0 / 43 ) / 3 9 1% (9/ 2 3 ) / 66 7% (4/ 6) / 10 0 % (5 / 5 ) ;外周神经感觉异常发生率达71 8% (79/ 110 )
出处 《江苏医药》 CAS CSCD 北大核心 2003年第1期23-25,共3页 Jiangsu Medical Journal
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  • 1成翼娟,戴红霞,宁宁.临床路径在膝关节镜手术患者中的应用研究[J].中华护理杂志,2004,39(7):489-491. 被引量:104
  • 2Beerblock K, Rinaldi Y, Andre T, et al. Bimonthly high dose leucovorin and 5-fluorouracil 48-hour continuous infusion in patients with advanced colorectal carcinoma[J ]. Cancer, 1997, 79(6): 1101- 1104. 被引量:1
  • 3De Gramont A ,Krulik M, Cady J, et al. High-dose folinic acid and 5-fluorourcil bolus and continuous infusion in advanced colorectal cancer[J]. Eur J Cancer Clin Oncol, 1988,24(9): 1499 -1503. 被引量:1
  • 4Goldberg RM, Sargent DJ, Morton RF, et al. A randomized controlled trial of fluorouraciL plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer[J ]. J Clin Oncol,2004,22( 1 ) :23 -30. 被引量:1
  • 5Feliu J,Vicent JM,Garcia-Giron C,et al.Phase Ⅱ study of UFT and oxaliplatin in first-line treatment of advanced colorectal cancer.Br J Cancer,2004,91:1758-1762. 被引量:1
  • 6Saigi E,Batiste-Alentorn E,Diaz N,et al.Phase Ⅱ study of weekly irinotecan(CPT-11) associated to protracted oral tegafur(TGF) in previously untreated,advanced colorectal cancer(ACRC).Journal of Clinical Oncology,2005,23:302S. 被引量:1
  • 7Eng C,Kindler HL,Schilsky RL,et al.Oral fluoropyrimidine treatment of colorectal cancer.Clin Colorectal Cancer,2001,1:95-103. 被引量:1
  • 8Douillard JY,Hoff PM,Skillings J,et al.Multicenter phase Ⅲ study of uracil/tegafur and oral leucovin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer.J Clin Oncol,2002,20:3605-3616. 被引量:1
  • 9Kondo K,Murase M,Kodera Y,et al.Feasibility study on protracted infusion 5-fluorouracil and consecutive low-dose cisplatin for advanced gastric cancer[J].Oncology,1996,53(1):64-67. 被引量:1
  • 10Wasserman E,Cuvier C,Lokier F,et al.Combination of oxaliplatin plus irinotecan in patients with gastrointestinal tumors:results of two indeendent phase Ⅰ studies with pharmacokinetics[J].J Clin Oncol,1999,17:1751-1759. 被引量:1

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