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慢性苯中毒和几种血液病的骨髓细胞形态学比较研究 被引量:1

A comparative study on morphological features of bone marrow cells among chronic benzene intoxication and some other hemopoietic disorders
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摘要 目的 探讨慢性苯中毒患者骨髓细胞的一些形态特征。方法 采用病例对照研究 ,将 9例慢性苯中毒患者的骨髓细胞分别和原发性骨髓增生异常综合征 (MDS)、慢性再生障碍性贫血 (CAA)和白细胞减少症三个对照组的骨髓细胞作对比 ,观察在病态造血方面的差异性。结果 慢性苯中毒与MDS在红系、粒 单核系、巨核系病态造血方面的差异均无显著性 (P >0 0 5) ,无鉴别诊断价值 ;但较CAA、白细胞减少症在三系病态造血方面明显严重 (P <0 0 5) ,具有鉴别诊断意义。结论 慢性苯中毒在发病过程中可表现和原发性MDS相类似的骨髓病态造血 。 Objective To explore morphological features of bone marrow cells in chronic benzene intoxication cases. Methods By case control study design, 9 cases of chronic benzene intoxication were examined for morphological features of bone marrow cells, compared with those in primary myelodysplastic syndrome (MDS), chronic aplastic anemia (CAA) and leukopenia respectively in order to find out the similarity and difference of the hematopoietic disorders among the induction and other origins. Results The examination on morphological features of erythrocytic series, granulate monocytic series and megakaryocytic series in chronic benzene intoxication revealed a similar pattern of morbid hematopiesis with MDS, but a different pattern from CAA and leukopenia. The differential diagnosis between benzene induced morphological features and MDS showed no clinical significance ( P >0 05), while significant difference between benzene intoxication group and CAA or leukopenia was shown respectively( P <0 05). Conclusion It suggested that morbid hematopoiesis of bone marrow in the course of benzene intoxication might somewhat resemble that in MDS, whereas its mechanism might still need to be investigated.
出处 《中国职业医学》 CAS 北大核心 2002年第6期5-7,共3页 China Occupational Medicine
关键词 慢性苯中毒 骨髓细胞形态 原发性骨髓增生异常综合征 慢性再生障碍性贫血 白细胞减少症 Chronic benzene intoxication Bone marrow cell morphology Primary myelodysplastic syndrome Chronic aplastic anemia Leukopenia
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