摘要
目的探讨14种高危型HPV病毒检测联合液基细胞学检查在宫颈癌筛查中的应用价值。方法采用整群抽样法,对该院2016年9月—2018年3月2 650例妇科患者及正常体检妇女展开宫颈癌筛查,入组对象均进行14种高危型HPV病毒检测与液基细胞学检查,最终以病理学检查为标准,评估筛查结果。结果该组2 650例研究对象经病理学检查诊断为炎症者2 258例,占比85.20%,CIN392例,占比14.80%,鳞癌5例,占比0.18%。使用不同检测方法发现,HPV的检测符合率为54.64%,TCT的检测符合率为47.55%,HPV+TCT检测符合率最高,达99.81%。数据明显高于HPV与TCT单独检测,且通过3种检查方法的真阳性、假阳性、真阴性、假阴性例数得出其敏感度、特异性与准确度,其结果为HOV的敏感度、特异性、准确度最低,分别为82.30%、89.89%、85.28%,而HPV+TCT的敏感度、特异性、准确度最高,分别为97.28%、94.78%、96.38%,均高于HPV与TCT单独检测,差异有统计学意义(P<0.05)。结论采用14种高危型HPV病毒检测联合液基细胞学检查在宫颈癌筛查中具有较高的应用价值,明显提高检查符合率与准确性,为患者及早诊断与治疗提供可靠依据。
Objective To investigate the value of 14 high-risk HPV virus detection combined with liquid-based cytology in cervical cancer screening.Methods The whole group sampling method was used to conduct cervical cancer screening for2 650 gynecological patients and normal physical examination women from September 2016 to March 2018.All the subjects were tested for high-risk HPV virus and liquid-based cytology examination,and finally the pathological examination as a standard,evaluate the screening results.Results 2 650 cases of this group were diagnosed as 2 258 cases of inflammation by pathology,accounting for 85.20%,CIN392 cases,accounting for 14.80%,and squamous cell carcinoma 5 cases,accounting for 0.18%.Using different detection methods,the detection rate of HPV was 54.64%,the coincidence rate of TCT was47.55%,and the highest coincidence rate of HPV+TCT was 99.81%.The data was significantly higher than that of HPV and TCT alone,and the sensitivity,specificity and accuracy were obtained by the number of true positive,false positive,true negative,and false negative cases of the three methods.The result was the sensitivity of HOV,specificity and accuracy were the lowest,82.30%,89.89%,and 85.28%,respectively.The sensitivity,specificity,and accuracy of HPV+TCT were the highest,which were 97.28%,94.78%,and 96.38%,respectively,both higher than HPV and TCT.The difference was statistically significant(P<0.05).Conclusion The combination of 14 high-risk HPV virus tests combined with liquid-based cytology has a high application value in cervical cancer screening,which significantly improves the compliance rate and accuracy of the examination,and provides a reliable basis for early diagnosis and treatment.
作者
黎晖
LI Hui(Department of Pathology,Quanzhou Maternal and Child Health Hospital,Children's Hospital,Quanzhou,Fujian Province,362000 China)
出处
《中外医疗》
2019年第6期7-9,共3页
China & Foreign Medical Treatment
