摘要
在278. 15～323. 15 K下采用静态平衡法测定了地高辛在乙醇、甲醇、异丙醇、甲醇-水体系(甲醇体积分数为80%)及乙醇-水体系(乙醇体积分数为80%、60%、40%、20%)中的溶解度数据,采用Apelblat方程、多项式经验方程和λh方程对地高辛的溶解度进行关联。实验结果表明,8种溶剂中,地高辛的溶解度均随温度的升高而增加,在80%乙醇水混合溶剂中溶解度最大,在20%乙醇水中溶解度最小,几种热力学模型对地高辛的关联效果也很好。经热力学理论分析,计算溶解焓与溶解熵可知地高辛的溶解过程为吸热过程。地高辛溶解度的测定及关联为其工业化纯化溶剂的选择提供重要理论依据。
The solubility of digoxin in methanol,ethanol,isopropanol and binary system of methanol-water solvent(the volume fraction of methanol for 80%),ethanol-water solvent(the volume fraction of ethanol for 80%,60%,40%,20%) were measured by an equilibrium method at 278. 15 ~ 323. 15 K.The modified Apelblat equation,empirical equation and the λh equation were selected to correlate the experimental data. The results showed that the solubility of digoxin in eight organic solvents all increased with temperature increasing.Digoxin has the highest solubility in 80% ethanol and the lowest in 20% ethanol. The solubilities of calculated values were in good agreement with the experimental results.Based on the thermodynamic theory analysis,the dissolution process and the dissolution entropy were calculated to know that the dissolution process of digoxin is an endothermic process.The determination and correlation of the solubility of digoxin provides an important theoretical basis for the selection of industrial purification solvents.
作者
刘兰云
孙永跃
李国兵
全灿
LIU Lan-yun;SUN Yong-yue;LI Guo-bing;QUAN Can(School of Chemistry and Chemical Engineering,Tianjin University of Technology,Tianjin 300384,China;School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;Division of Metrology in Chemistry,National Institute of Metrology,Beijing 100029,China)
出处
《化学试剂》
CAS
北大核心
2019年第3期246-252,共7页
Chemical Reagents
关键词
地高辛
溶解度
静态平衡法
关联
Digoxin
solubility
static equilibrium method
coorelation
