摘要
骨关节炎是临床常见的慢性疾病之一,临床表现为关节疼痛、僵硬和关节畸形等,病理改变为软骨退行性变性和消失。目前,骨关节炎诊断主要依据临床表现和影像学检查,但X线平片、CT检查不能反映关节软骨结构变化,MRI检查存在检查所需时间长、价格高等局限性并非检查首选。检测软骨寡聚基质蛋白、印度刺猬蛋白、Ⅱ型胶原螺旋肽等生物学标志物可在关节软骨损伤早期对骨关节炎进行诊断。本文就骨关节炎早期诊断生物学标志物的研究进展作一综述。
Osteoarthritis is one of the most common chronic diseases,characterized by pain,stiffness and joint deformity.The pathological changes included degenerative degeneration and disappearance of cartilage.At present,the diagnosis is mainly based on clinical manifestations and imaging examination.Neither X-ray nor CT examination can reflect the structural changes of articular cartilage,meanwhile MRI is not the first examination method because of its long inspection time and high price.Therefore,it is of great significance to find the early diagnosis methods of osteoarthritis.Laboratory markers such as cartilage oligomeric matrix protein,India hedgehog protein,and type Ⅱ collagen helix peptide can be used to diagnose osteoarthritis at the early stage of articular cartilage injury.This paper reviews the research progress of biomarkers for early diagnosis of osteoarthritis.
出处
《中华实用诊断与治疗杂志》
2017年第11期1142-1144,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
陕西省科学技术研究发展计划项目(2014K11-03-06-07)
关键词
骨关节炎
软骨寡聚基质蛋白
印度刺猬蛋白
Ⅱ型胶原螺旋肽
Osteoarthritis
cartilage oligomeric matrix protein
India hedgehog
typeⅡ collagen helix peptide
