摘要
目的探讨角膜塑形镜联合体积分数0.01%阿托品控制青少年近视的临床效果。方法青少年近视患者94例(175眼),随机分为观察组47例(86眼)和对照组47例(89眼),2组均配戴角膜塑形镜,观察组同时给予体积分数0.01%阿托品滴眼,1滴/d。记录2组治疗前、治疗6个月后眼轴长度、瞳孔调节幅度、瞳孔直径、泪膜破裂时间,计算差值并进行比较。结果观察组治疗6个月后与治疗前眼轴长度差值[(0.11±0.09)mm]较对照组[(0.25±0.11)mm]小(P<0.05),瞳孔直径差值[(1.02±0.59)mm]较对照组[(0.05±0.85)mm]大(P<0.05);观察组、对照组治疗6个月后与治疗前瞳孔调节幅度差值[(-0.03±0.02)、(-0.05±0.04)D]、泪膜破裂时间差值[(-1.01±0.47)、(-1.04±0.59)s]比较差异均无统计学意义(P>0.05)。结论角膜塑形镜联合体积分数0.01%阿托品控制青少年近视效果优于单纯配戴角膜塑形镜,其机制可能与二者联合应用发挥协同作用,控制眼轴增长速度有关。
Objective To explore the clinical effect of orthokeratology lens combined with 0.01% atropine on juvenile myopia.Methods Ninety-four myopic teenagers(175 eyes)were randomly divided into observation group(n=47,86 eyes)and control group(n=47,89 eyes).Based on orthokeratology lens in both groups,observation group received0.01% atropine a drop once a day.The length of the ocular axis,the range of pupillary accommodation amplitude,the diameter of pupil and the tear break-up time were recorded before and after 6-month treatment,and the difference of the indexes were compared between two groups.Results The difference value of ocular axis length before and after treatment was significantly smaller and the difference value of diameter of pupil was significantly larger in observation group((0.11±0.09),(1.02±0.59)mm)than that in control group((0.25±0.11),(0.05±0.85)mm)(P<0.05).There were no significant differences in the difference values of amplitude accommodation before and after treatment((-0.03±0.02)Dvs(-0.05±0.04)D)and tear break-up time((-1.01±0.47)s vs(-1.04±0.59)s)between observation group and control group(P>0.05).Conclusion The combination of orthokeratology lens and 0.01% atropine is more effective than the single use of orthokeratology lens in treating young myopia,which might be correlated with the control of the change in axial length by synergistic effect of them two.
出处
《中华实用诊断与治疗杂志》
2017年第11期1102-1103,共2页
Journal of Chinese Practical Diagnosis and Therapy
基金
河南省科技攻关计划项目(2011020183)
