摘要
目的:采用网状Meta分析的研究方法,以西医常规治疗为共同参照,对比丹参川芎嗪注射液、丹参酮注射液、灯盏细辛注射液、肾康注射液对于慢性肾衰竭的临床疗效。方法:计算机检索MEDLINE、EMbase、PubMed、CBM、WanFang Data、CNKI等主要电子数据库中有关丹参川芎嗪注射液、丹参酮注射液、灯盏细辛注射液、肾康注射液治疗慢性肾衰竭的随机对照试验,并手工检索相关期刊,追溯纳入研究的参考文献。由2位评价者根据纳入和排除标准独立选择文献、收集资料后使用Cochrane Reviewer’s Handbook 5.1中的方法进行文献质量评价。运用Stata14.0和R软件GEMTC程序包进行统计分析,以比值比及95%可信区间为效应指标,比较各治疗措施疗效差异,并进行疗效排序。结果:纳入34个RCT,合计2217例慢性肾衰竭患者,涉及5种治疗措施。结论:本次网状Meta分析结果显示丹参川芎嗪注射液、灯盏细辛注射液、肾康注射液联合西医常规治疗均优于单用西医常规治疗。在所纳入的治疗措施排序中,肾康注射液联合西医常规治疗对于降低慢性肾衰竭血肌酐的疗效排序最高。由于纳入研究的质量相对偏低,以上结论尚需日后进一步开展更多严格设计的大规模、高质量的随机临床试验加以验证。
Objective:To compare the clinical efficacy of Danshen Chuanxiongqin injection(丹参川芎嗪注射液),Tanshinone injection(丹参酮注射液),Dengzhan Xixin injection(灯盏细辛注射液)and Shenkang injection(肾康注射液)on chronic renal failure with the method of reticular Meta-analysis and the conventional treatment of western medicine as a common reference.Methods:Computer-retrieved MEDLINE,EMbase,PubMed,CBM,WanFang Data,CNKI and other major electronic databases for randomized controlled trials of Danshen Chuanxiongqin injection,Tanshinone injection,Dengzhan Xixin injection and Shenkang injection in the treatment of chronic renal failure.Manually search for relevant journals and trace the references included in the study.The literature quality was evaluated by two evaluators independently selecting the literature according to the inclusion and exclusion criteria and collecting the data using the method in Cochrane Reviewer's Handbook 5.1.Statistical analysis was performed using Stata14.0 and R software GEMTC packages.The odds ratio and 95%confidence interval were used as the effect indicators to compare the therapeutic effects of each treatment and to rank the therapeutic effects.Results:A total of 2217 patients with chronic renal failure were enrolled in 34 RCTs,involving 5 treatments.Conclusion:The results of reticular meta-analysis showed that Danshen Chuanxiongqin injection,Dengzhan Xixin injection and Shenkang injection combined with western medicine were better than conventional western medicine.Among the treatment measures included,Shenkang injection combined with routine western medicine has the highest effect on reducing serum creatinine in chronic renal failure.Due to the relatively low quality of the included studies,the above conclusions need to be further verified by more rigorously designed large-scale,high-quality randomized clinical trials.
作者
包能
于翔
陈笑
孔薇
BAO Neng;YU Xiang;CHEN Xiao;KONG Wei(Nanjing University of Traditional Chinese Medicine,Nanjing Jiangsu 210029,China;Nanjing Chinese Medicine Hospital Affiliated to Nanjing University of Traditional Chinese Medicine,Nanjing Jiangsu 210001,China)
出处
《中医药导报》
2019年第17期91-100,124,共11页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
2018年江苏省研究生实践创新计划(SJCX18_0483)
关键词
丹参川芎嗪注射液
灯盏细辛注射液
丹参酮注射液
肾康注射液
慢性肾衰竭
慢性肾功能不全
网状Meta分析
Danshen Chuanxiongqin injection(丹参川芎嗪注射液)
Dengzhan Xixin injection(灯盏细辛注射液)
Tanshinone injection(丹参酮注射液)
Shenkang injection(肾康注射液)
chronic renal failure
chronic renal insufficiency
reticular Meta-analysis