摘要
实验用Wistar大鼠147只,分为7组:1.林县自来水;2.浓缩5倍林县自来水;3.0.02%肌氨酸乙酯盐酸盐林县自来水溶液;4.林县井头大队池水;5.浓缩5倍池水;6.0.02%肌氨酸乙酯盐酸盐池水溶液;7.井头大队井水。分别以上述饮水或溶液加等量玉米面混合作为动物饲料进行诱癌实验。结果,除第1组前胃上皮未发现病变外,其余各组前胃上皮均呈现不同程度的瘤前病变和癌病前变。林县自来水和池水分别加入肌氨酸乙酯盐酸盐并诱发了大鼠食管上皮乳头状增生或乳头状瘤(3组和6组)。作者认为以上几种饮用水可能含有致瘤成份,与人食管癌的发生可能有关。
In this experimental study,147 male and female Wistar rats were divid- ed into 7 groups: group 1, tap water from Linxian County; group 2,tapwater condensed five times from Linxian County; Croup 3, 0.02% solutionof sarcosine-eth ylester hydrochloride in the tap water of Linxian County;qroup 4, pool water from Jing-Tou Production Brigade, Linxian County;group 5, pool water condensed five times; group 6, 0.02% solution of sa-rcosine ethylester hydrochloride in pool water; group 7,well water in Jing-Tou Pro??ction Brigade. In these groups, the animals were fed with mixtureof corn-flour plus the equivalent drinking water or solution mentioned abo-ve The experimental results are as follows:except qroup 1, in which thepathological lesions of the forestomach epithelium in rats were not found,pretumourous and precancerous lesions of various degrees were noticed inthe forestomach of the rats. Papillomatic proliferation and papillomas ofthe esophaqus were induced in group 3 and group 6. We think that thedrinking water mentioned above must contain tumourigenic substance, wh-ich is related to human esophageal carcinoma in this area.
出处
《郑州大学学报（医学版）》
CAS
1984年第4期1-6,共6页
Journal of Zhengzhou University(Medical Sciences)
关键词
肿瘤
饮水
大鼠
胃
食管
neoplasms water
rats esophagus
stomach
