摘要
目的 :分析不同术式对结直肠癌患者CK20mRNA的表达影响及其在结直肠癌治疗中的临床意义。方法 :选取2014年4月～2016年3于本科室240例胃肠道手术患者,采用随机数字表随机分成观察组和对照组,各120例。对照组采用开腹式手术,实验组患者采用腹腔镜手术,并对两组患者手术的基本情况、术后切口的愈合以及CK20mRNA的表达情况进项比较。结果 :观察组患者切口长度(8.28±2.17)cm、手术时间(90.25±10.28)min、出血量(122.18±12.03)mL以及肛门排气时间(5.16±4.63)d均显著优于对照组患者切口长度(13.86±3.69)cm、手术时间(111.36±10.24)min、出血量(188.58±20.53)mL以及肛门排气时间(8.22±5.24)d;观察组患者切口甲级愈合率71.67%、乙级愈合率25.83%、丙级、愈合率2.50%均显著优于对照组患者切合甲级愈合愈合率36.67%、乙级愈合率48.33%、丙级愈合率10.00%,具有显著统计学意义,比较两组患者术前术后CK20mRNA的表达,观察组患者术前外周血中CK20mRNA阳性表达率为80.83%,术后阳性表达率为81.67%;对照组患者术前阳性表达率为79.17%,术后阳性表达率为80.83%,差异无统计学意义。结论 :腹腔镜辅助下行结直肠癌根治术与开腹手术一样,并不增加外周静脉血C K20 m R N A的阳性率和术后肿瘤血循环微转移的危险性。
Objective To analyze the effect of different surgical methods on the expression of CK20 mRNA in colorectal cancer patients and its clinical significance in the treatment of colorectal cancer.Methods 240 patients with gastric intestinal surgeryrandomly divided into observation group and control group were randomly divided into observation group and control group,each of 120 cases from April 2014 to March 2016.While the control group was treated with open surgery,experimental group were treated by laparoscopic surgery and of two groups of patients basic situation,postoperative incision healing and the expression of CK20 mRNA input.Results Patients with incision length(8.28±2.17)cm,the operation time(90.25±10.28)min,the amount of bleeding(122.18±12.03)ml and anal exhaust time(5.16±4.63)d were significantly better than the control group of patients with incision length(13.86±3.69)cm,the operation time(111.36±10.24)min the amount of bleeding,(188.58±20.53)ml and anal exhaust time(8.22±5.24)d;observation group of patients with grade a healing rate 71.67%,B 25.83%,C healing rate and healing rate of 2.50%was significantly better than the control group of patients with grade a healing rate,healing rate of 48.33%36.67%class B and C with the healing rate was 10%.Statistical significance,two groups of the patients were compared before and after the expression of CK20 mRNA,patients in the observation group preoperative peripheral blood CK20 mRNA positive rate was 80.83%,postoperative positive expression rate was 81.67%;the control group The positive expression rate was 79.17%,the positive expression rate was 80.83%,the difference was not statistically significant.Conclusion Laparoscopic assisted radical resection of colorectal cancer is the same as open surgery,does not increase the positive rate of peripheral venous blood K20 m R N A C and the risk of postoperative tumor blood circulation.
作者
邱晓峰
杨振熙
Qiu Xiao-feng;Yang Zhen-xi(General Surgery Department of the Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China)
出处
《湖南师范大学学报（医学版）》
2019年第1期71-74,共4页
Journal of Hunan Normal University(Medical Sciences)
关键词
不同术式
结直肠癌
CK20MRNA
临床意义
different surgical methods
colorectal cancer
CK20mRNA
clinical significance
