摘要
目的:分析中老年原发性高血压患者血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)、促肾上腺皮质激素(ACTH)及甲状腺激素的检测结果。方法:214例中老年(≥45岁)原发性高血压患者(EH组)进行血浆AngⅡ、ALD、ACTH、总三碘甲状腺原氨酸(TT3)、游离三碘甲状腺原氨酸(FT3)、甲状腺素(T4)、促甲状腺激素(TSH)检测,并与同期我院的135例中老年(≥45岁)健康者(对照组)检测结果对比。结果:EH组AngⅡ、ALD、ACTH含量显著高于对照组,TT3、FT3显著低于对照组,差异具有统计学意义;两组T4和TSH差异不显著;EH组45-59岁患者AngⅡ和ALD显著低于≥60岁者,差异具有统计学意义;EH组Ⅰ级、Ⅱ级、Ⅲ级AngⅡ、ALD、ACTH水平依次显著升高,TT3和FT3依次显著降低,差异具有统计学意义;治疗后EH组AngⅡ、ALD和ACTH水平显著降低,TT3、FT3水平显著增高,差异具有统计学意义。结论:AngⅡ、ALD、ACTH和甲状腺激素可作为中老年原发性高血压患者病情程度检测和预后指标,临床诊断意义重大。
Objective To analyze the detection results of angiotensin II(Ang II), aldosterone(ALD), adrenocorticotrophic hormone(ACTH) and thyroid hormone in elderly patients with essential hypertension. Methods A total of 214 middle-agedpatients(≥45 years old) with essential hypertension(EH group) receiveddetection of Ang II, ALD, ACTH, total triiodothyronine(TT3), free triiodothyronine(FT3), thyroxine(T4) and thyroid stimulating hormone(TSH), and the results were compared with those of 135 middle-aged(≥45 years) healthy subjects(control group). Results The levels of Ang II, ALD, ACTH in EH group were significantly higher than those in control group while levels of FT3 and TT3 were significantly lower. T4 and TSH showedno significant differences between the two groups. The levels of Ang II and ALD in patients aged 45-59 years old were significantly lower than those in patients ≥ 60 years old in RH group. The levels of Ang II, ALD and ACTHsignificantly increased successively from grade I, II to III in EH group while FT3 and TT3 significantly decreased successively. After treatment, the levels of Ang II, ALD and ACTH in EH group were significantly decreased, and the levels of FT3 and TT3 were significantly increased. Conclusion Ang II, ALD, ACTH and thyroid hormones can be used as the indicators for detecting the severity of essential hypertension and prognosis in middle-aged patients.
出处
《湖南师范大学学报（医学版）》
2018年第2期125-128,共4页
Journal of Hunan Normal University(Medical Sciences)
