摘要
目的 :观察以口服盐酸羟考酮缓释片为背景的给药进行中重度癌痛滴定,分析滴定的疗效及安全性,以期合理的羟考酮缓释制剂滴定改善中重度癌痛患者的疼痛,提高患者的生活质量。方法 :选取在2011年4月到2013年6月以116例伴有中重度癌痛患者为研究对象,爆发痛时应立即完成BPI量表。服用盐酸羟考酮缓释片10mg后1小时进行疼痛评估,如疼痛不能控制,釆用即释吗啡进行滴定,直至疼痛控制。记录达到疼痛控制所需滴定周期数,同时还记录了用药前后的生活质量改善及用药安全性的评估。结果 :入选116例癌痛患者,中度癌痛104例,重度癌痛有12例,男性80例,女性36例,在治疗过程中,不同性别的疼痛控制率的比较,卡方值=0.006,P=0.938,差别无显著性差异;不同疼痛性质的疼痛控制率的比较,卡方值=2.377,P=0.305比较差别无显著性差异;不同疼痛程度的疼痛控制率的比较,卡方值=20.135,P=0.000,比较差别有显著性差异;不同年龄的疼痛控制率的比较,卡方值=0.041,P=0.839,比较差别无显著性差异。不同程度疼痛滴定周期的比较,t=-3.683,P=0.13,疼痛程度对疼痛控制周期有影响;入组前后并发症的比较,卡方=33.294,P=0.000,患者入组后并发症状中恶心、呕吐占6.90%,便秘占70.69%,尿储留患者3.45%,呃逆占3.45%,约8.62%的患者无其他明显并发症。结论 :盐酸羟考酮缓释制剂为背景的癌痛治疗,在中重度癌痛滴定中具有较理想的疗效及明显的优势。该方法步骤简单,容易掌握,便于普及,且不良反应少,可以显著改善癌痛患者生活质量。
Objective To observe the oral oxycodone hydrochloride sustained-release tablets were administered the background of moderate to severe cancer pain titration, titration analysis of efficacy and safety in order to reasonably extended release formulation of oxycodone titration improve moderate to severe cancer pain pain, improve the quality of life of patients. Methodsin April 2011 to June 2013 to 116 cases with moderate to severe cancer pain patients in this study, should be completed immediately BPI pain scale outbreak. Taking oxycodone hydrochloride sustained-release tablets 10 mg one hour after pain assessment, such as pain can not be controlled, preclude the use of immediate-release morphine titrated until pain control. Record achieve pain control titration number of cycles needed, while also recording the life quality improvement and evaluation of drug safety before and after treatment. Selected results of 116 cases of cancer pain, moderate pain 104 cases, 12 patients with severe cancer pain, male 80 cases, female 36 cases, in the course of treatment, pain control to compare different sex ratio, chi-square value = 0.006, P=0.938, no significant difference difference; compare pain control rate of the different nature of pain, the chisquare value = 2.377, P=0.305 comparing the difference was not significant difference varying degrees of pain Comparison of pain control rate, chi-square value = 20.135, P=0.000, there was a significant difference comparing the difference; compare different ages pain control rate, the chi-square value = 0.041, P=0.839, comparing the difference was not significant difference. Comparison of different intensity of pain titration period, t=-3.683, P=0.13, the degree of pain pain control cycle impact; the groups before and after comparison of complications, chi-square =33.294, P=0.000, patient into After the set of concurrent symptoms of nausea, vomiting accounted for 6.90%, accounting for 70.69 percent of constipation, urinary retention in patients with 3.45%, accounting for 3.45% of hi
出处
《湖南师范大学学报（医学版）》
2015年第4期38-40,共3页
Journal of Hunan Normal University(Medical Sciences)
基金
多药联合泵入治疗癌性疼痛临床研究(2013-J2-13)
关键词
中重度癌痛
盐酸羟考酮缓释片
临床分析
with moderate to severe cancer pain
oxycodone hydrochloride sustained-release tablets
