摘要
目的:应用Meta分析探讨肺部多叶病变与老年获得性肺炎住院患者预后影响的相关性。方法:检索中国全文期刊数据库、万方数据知识服务平台、维普期刊全文数据库、中国生物医学文献数据库、PubMed和EMBase,检索起止时间均为建库至2014年7月,按照纳入和排除标准收集所有有关的研究文献。采用RevMan 5.2软件进行Meta分析,进行异质性检验并计算比值比(odds ratio,OR)及其95%可信区间(95%con dence interval,95%CI),采用漏斗图和Egger法评估发表偏倚,并进行敏感性分析。结果:最终纳入10篇文献,1 836例研究对象,其中病例(死亡组)487例,对照(存活组)1 349例。Meta分析结果显示:肺部多叶病变与老年获得性肺炎预后相关(合并OR值为3.22,95%CI为1.84~5.63)。结论:肺部多叶病变会增加老年获得性肺炎住院患者的预后死亡风险。
Objective: To explore the correlation regarding the prognostic influence between multiple lung lobe lesions and acquired pneumonia in hospitalized elderly patients by a Meta-analysis. Methods: We collected all studies which investigated the correlation regarding the prognostic effect between multiple lung lobe lesions and acquired pneumonia by searching China National Knowledge Infrastructure, Wanfang Database, Chinese Science and Technology Periodical Database, Chinese Biological Medical Literature Database, PubMed, and EMBase in accordance with the inclusion and exclusion criteria. hTe retrieval limit time of searches was from databases establishment to July 2014. hTe Meta-analysis was performed by using RevMan5.2 sotfware. We calculated the odds ratio (OR) and 95% conifdence interval (95% CI) by using heterogeneous tests.Publication bias was assessed by Egger’s test and funnel plot, and the sensitivity was analyzed. Results: Ten studies involving 1 836 patients were ifnally included, with 487 cases (the dead group) and 1 349 controls (the survival group). The Meta-analysis demonstrated that multiple lung lobe lesions was highly correlated with the prognosis for the aged acquired pneumonia (OR=3.22, 95% CI 1.84 to 5.63). Conclusion: Multiple lung lobe lesions increase the risk of death in the prognosis of the aged patients with acquired pneumonia.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2014年第11期1118-1124,共7页
Journal of Central South University ：Medical Science
