摘要
急性加重是慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)疾病进程中的重要事件,给患者的生活和疾病病程造成严重后果,同时带来巨大的社会和经济负担,急性加重的预防有着重要的临床意义。研究证实长效支气管舒张药、吸入性糖皮质激素、磷酸二酯酶4抑制药、茶碱、抗氧化药、免疫调节药、大环内酯类抗生素、疫苗等药物治疗可有效预防COPD急性加重的发生。非药物干预如肺康复、氧疗及无创机械通气等在预防COPD急性加重中也发挥一定的作用。
Acute exacerbation is an important event in the development of chronic obstructive pulmonary disease(COPD). It is now known that acute exacerbations can negatively affect patients' quality of life and natural course of COPD, leading to heavy burden of society and economy. Preventive measures are very important for acute exacerbations of COPD. Long-acting bronchodilators, inhaled corticosteroids, phosphodiesterase 4 inhibitor, theophylline, antioxidants, immunomodulators, macrolides, and vaccine have been demonstrated to be efficient in prevention of COPD development. Non-pharmacological interventions, such as rehabilitation, long-term oxygen therapy, and non-invasive ventilation, are also useful strategies to prevent the acute exacerbations in patients with COPD.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2014年第8期861-867,共7页
Journal of Central South University ：Medical Science
基金
国家临床重点专科建设项目和国家自然科学基金(81370143
81170036)~~
关键词
慢性阻塞性肺疾病
急性加重
预防
chronic obstructive pulmonary disease
exacerbations
prevention
